Integrative Clinical Research (Advances in Experimental Medicine and Biology, 1375)

This book embraces a comprehensive range of research across several disciplines, providing insights and fresh perspectives on clinical topics, emphasizing the integrative medical approach. The book also addresses an increasing role of artificial intelligence in the development of clinical methodologies, research, and patient-oriented care. The authors share expertise and experience in rehabilitation medicine whose healing-effects particularly depend on the interaction between the therapist and patient. Chapters present novel approaches in manual rehabilitative therapy of common painful and disabling neuromuscular ailments, exemplified but not limited to low back pain and migraine. The myofascial trigger point release therapy includes specific manipulations to muscles and connective tissue which reduce pain. Other chapters address the issues of providing long-range medical care to older adults burdened with chronic diseases, notably hypoxia-related pathologies and their sequalae, pointing to the advantages of care provided by a single primary care physician. Changing paradigm of care is essential in chronic atherosclerosis-based diseases like cardiovascular disorders or diabetes. Chapters provide results of international cohort studies on predictive factors for the long-range progress of such ailments based on anthropometric and lifestyle indicators. The book aims to meet the increasing interest and importance to patients of integrative health therapies. Medical rehabilitation and lifestyle changes increasingly gain scientific support in difficult-to-treat chronic conditions and should be integrated in a controlled manner into conventional medicine. The book is addressed to physiotherapists, medical scientists and clinicians, and allied healthcare professionals. Contents 6 Artificial Intelligence and Precision Medicine: A Perspective 8 1 Introduction 8 2 Methods 9 3 Genetics, Omics, and Precision Medicine 10 4 Oncology 11 5 Radiology and Radiogenomics 11 6 Artificial Intelligence, Precision Medicine, and Recent COVID-19 Pandemic 12 7 Sensitivity of Genomic Data Concerning Public Health 13 8 Summary and Conclusions 14 References 15 Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge 19 1 Background 19 2 Database Search 20 3 Search Results 20 4 Physiotherapy in Orthopedic Diseases 21 5 Physiotherapy in Neurologic Diseases 24 6 Physiotherapy in Diabetes Mellitus 24 7 Pedobarography in Rheumatology 25 8 New Technologies in Rehabilitation 25 9 Conclusions 26 References 26 Quantum Medicine: A Role of Extremely Low-Frequency Magnetic Fields in the Management of Chronic Pain 29 1 Introduction 30 2 Methods 31 2.1 Patients and Study Design 31 3 Results 31 4 Discussion 32 References 34 Manual Therapy Approach to the Extraocular Muscles in Migraine Treatment: A Preliminary Study 35 1 Introduction 36 2 Methods 36 2.1 Patients and Study Design 37 2.2 Therapeutic Interventions 38 2.3 Statistical Analysis 39 3 Results 39 4 Discussion 40 References 42 Capacitive and Resistive Electric Transfer Therapy: A Comparison of Operating Methods in Non-specific Chronic Low Back Pain 44 1 Introduction 45 2 Methods 45 2.1 Patients and Study Design 45 2.2 Treatment Interventions 46 2.2.1 Thermal Imaging 46 2.2.2 Digital Pressure Algometry 46 2.3 Statistical Analysis 47 3 Results 47 4 Discussion 49 References 50 Serum Impedance in Children with Recurrent Respiratory Infections 52 1 Introduction 52 2 Methods 53 3 Results 55 4 Discussion 55 References 58 Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek 60 1 Introduction 60 2 Methods 61 2.1 Statistical Analysis 61 3 Results 62 4 Discussion 62 References 66 The Impact of Change in Hospital Admissions When Primary Care Is Provided by a Single Primary Care Physician: A Cohort Study A... 67 1 Introduction 68 1.1 Intervention 68 1.2 Outcome Measures 69 1.3 Sensitivity Analysis 69 2 Results 69 3 Comments 69 4 Study Limitations 71 References 72 Risk of Falls in Patients Aged Over 65 in the Context of the Treatment Facility 73 1 Introduction 73 2 Methods 74 2.1 Study Design and Participants 74 2.2 Data Analysis 75 3 Results 75 4 Discussion 77 References 81 Anthropometric Indices as Long-Term Predictors of Diabetes in Impaired Fasting Glucose Metabolism: Findings in the PURE Study ... 83 1 Introduction 83 2 Methods 84 2.1 Study Design 84 2.2 Participants and Measurements 85 2.3 Statistical Analysis 85 3 Results 85 4 Discussion 88 References 91 Cardiovascular Risk Factors Drive Impaired Fasting Glucose to Type 2 Diabetes: Findings After a 9-Year Follow-Up in the PURE S... 93 1 Introduction 94 2 Methods 94 2.1 Study Design and Participants 94 2.2 Measurements 95 2.3 Statistical Analysis 96 3 Results 96 4 Discussion 100 References 101 Sleep-Disordered Breathing in Pregnancy 104 1 Introduction 105 2 Methods 105 3 Results 106 4 Discussion 108 References 111