Insulin Signaling: From Cultured Cells To Animal Models (frontiers In Animal Diabetes Research)

invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Every effort has been made to ensure that the advice and information in this book is true and accurate at the time of going to press. However, neither the publisher nor the authors can accept any legal responsibility or liability for any errors or omissions that may be made. In the case of drug administration, any medical procedure or the use of technical equipment mentioned within this book, you are strongly advised to consult the manufacturer's guidelines. ## British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library ## Library of Congress Cataloging in Publication Data A catalog record for this book has been requested ISBN 0-203-30295-8 Master e-book ISBN ISBN 0-203-34632-7 (Adobe e-Reader Format) ISBN 0-415-27174-6 (Print Edition) This volume is dedicated to the loving memory of Professor Dezider ('Dijon') Grunberger (1922Grunberger ( -1999)). pjwstk|402064|1435435002 CONTENTS Foreword ix Preface to the Series xi Preface xiii Contributors xv I. Structural Aspects of the Insulin Receptor and its Downstream Effectors With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to provide a state-of-the-art reference for graduate researchers and students in diabetes and endocrinology. Insulin Signaling is a comprehensive study of the regulation of molecular events by insulin at a cellular level, utilizing experimental techniques ranging from molecular systems through phenotypic expression in transgenic and knockout models Content: 1. Structural aspects of the insulin receptor and its downstream effectors -- 2. Insulin signaling cascades -- 3. Molecular aspects of insulin action -- 4. Transgenics and gene knockout models of insulin action. Insulin receptor mRNA is translated by ribosomes at the rough endoplasmic reticulum (ER).