Insulin Resistance: The Metabolic Syndrome X (Contemporary Endocrinology, 12)

In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights. The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.

gerald Reaven, The Discoverer Of Syndrome X, And A Panel Of World-class Investigators Thoughtfully Summarize Our Current Understanding Of How Insulin Resistance And Its Compensating Hyperinsulinemia Play A Major Role In The Pathogenesis And Clinical Course Of High Blood Pressure And Cardiovascular Disease-the So-called Diseases Of Western Civilization. These Distinguished Authorities Detail, For The First Time, The Pathophysiological Consequences And The Clinical Syndromes, Excluding Type 2 Diabetes, Related To Insulin Resistance. They Also Examine The Genetic And Lifestyle Factors That Contribute To The Wide Differences In Insulin Action That Exist In The Population At Large. Timely And Authoritative, Insulin Resistance: The Metabolic Syndrome X Illuminates The Full Importance Of Insulin Resistance As A Major Cause Of Hypertension, Heart Disease, And Polycystic Ovary Syndrome.

the Book Contains Black-and-white Illustrations.

gerald Reaven, The Discoverer Of Syndrome X, And A Panel Of World-class Investigators Thoughtfully Summarize Our Current Understanding Of How Insulin Resistance And Its Compensating Hyperinsulinemia Play A Major Role In The Pathogenesis And Clinical Course Of High Blood Pressure And Cardiovascular Disease-the So-called Diseases Of Western Civilization. These Distinguished Authorities Detail, For The First Time, The Pathophysiological Consequences And The Clinical Syndromes, Excluding Type 2 Diabetes, Related To Insulin Resistance. They Also Examine The Genetic And Lifestyle Factors That Contribute To The Wide Differences In Insulin Action That Exist In The Population At Large. Timely And Authoritative, Insulin Resistance: The Metabolic Syndrome X Illuminates The Full Importance Of Insulin Resistance As A Major Cause Of Hypertension, Heart Disease, And Polycystic Ovary Syndrome.

Front Matter....Pages i-x Front Matter....Pages 1-1 Genetics of Insulin Resistance....Pages 3-18 Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes....Pages 19-33 Fetal Effects on Insulin Resistance and Glucose Tolerance....Pages 35-49 Obesity and Insulin Resistance....Pages 51-81 The Role of Body Fat Distribution in Insulin Resistance....Pages 83-96 Physical Activity and Insulin Resistance in Man....Pages 97-120 Insulin Resistance in Smokers and Other Long-Term Users of Nicotine....Pages 121-136 Front Matter....Pages 137-137 Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase....Pages 139-158 NMR Studies on the Mechanism of Insulin Resistance....Pages 159-177 Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms ....Pages 179-195 The Role of the Liver in Insulin Action and Resistance....Pages 197-231 The Pathophysiological Consequences of Adipose Tissue Insulin Resistance....Pages 233-246 Insulin Action and Endothelial Function....Pages 247-263 Front Matter....Pages 265-265 Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk ....Pages 267-280 Insulin Resistance and Blood Pressure....Pages 281-308 Microalbuminuria and Insulin Resistance....Pages 309-316 PAI-1, Obesity, and Insulin Resistance....Pages 317-332 Insulin Resistance and Cardiovascular Disease....Pages 333-346 Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome....Pages 347-365 Back Matter....Pages 367-374