Insulin Resistance and Insulin Resistance Syndrome (Frontiers in Animal Diabetes Research, 5)

Focused on basic experimental diabetes research, this text is a useful resource for graduate students, research fellows, basic academic and pharmacological researchers, and clinic investigators. Fifty-one international specialists discuss the mechanisms of insular resistance, as discerned from a variety of animal models. Nineteen chapters explore metabolism and hypertension, molecular and genetic aspects, and aging. A sampling of topics include: the roles of insulin resistance and glycogen synthesis in liver, muscle and adipose tissue; molecular features of insulin resistance, obesity and type 2 diabetes in non-human primates; and the effect of age on the emergence of insulin resistance. Preliminaries......Page 1 CONTENTS......Page 6 Preface to the Series......Page 8 Preface......Page 10 Contributors......Page 12 1 Insulin Resistance and Glycogen Synthesis: Roles in Liver, Muscle and Adipose Tissue......Page 18 2 Gestational Diabetes and Maternal Insulin Resistance in the C57BLKS/JLeprdb/
Mouse......Page 36 3 Role of Protein-Tyrosine Phosphatases in Insulin Action and Insulin Resistance......Page 50 4 Hypertension and Insulin Resistance in the Wistar Fatty Rat......Page 66 5 Cardiovascular Disease in the Insulin-Resistant, Atherosclerosis-Prone JCR :LA-cp Rat......Page 74 6 The C57BL/6J Mouse as a Model of Insulin Resistance and Hypertension......Page 88 7 Molecular Features of Insulin Resistance, Obesity and Type 2 Diabetes in Non-human promates......Page 104 8 Effects of Genetic Alterations of Glut4 on Insulin Sensitivity......Page 140 9 Insulin Signaling Pathway and GLUT4-mediated Glucose Transport in the insulin resistant muscle......Page 162 10 Which Genes are Important in the Development of Type 2 Diabetes?......Page 190 11 Leptin and Insulin Resistance in Rodent Models......Page 202 12 Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance......Page 210 13 D-chiro-inositol and Insulin Resistance: An Allosteric Point of View......Page 226 14 Glucagon-like Peptide-1, Exendin and Insulin Sensitivity......Page 250 15 Insulin Resistance and the Autonomic Nervous System......Page 278 16 Hypothalamic Role in the Insulin Resistance Syndrome......Page 286 17 Insulin Resistance – Emerging Therapies for Affected Sites......Page 328 18 Effect of Age on the Emergence of Insulin Resistance......Page 352 19 Postnatal and Adult Insulin Sensitivity and Metabolism in Progeny of Nutritionally Compromised Mothers......Page 364 Index......Page 378 Type Ii Diabetes Has Developed Into A Global Epidemic, With Nearly 20 Type Ii Patients For Every Type I Individual. Preceding The Onset Of Type Ii Diabetes Is A Prolonged Episode Of Insulin Resistance Featuring A Host Of Detrimental Symptoms. This Period Comprises A Disease Referred To As Insulin Resistance Syndrome Or Metabolic Syndrome. Insulin Resistance And Insulin Resistance Syndrome Deals With The Cellular And Whole Body Pathogenic Mechanisms And Phenotypic Expressions In Various Models Of Insulin Resistance. Leaders In The Field Provide Their Perspectives On The Mechanisms Of Insulin Resistance, As Observed In Various Animal Models. While The Exact Mechanism Underlying Resistance To Insulin Is Unknown, The Authors Review Many Of The Significant Factors. A Series Of Chapters On Metabolic Syndrome Discusses Its Possible Insulin Resistance-associated Pathophysiology With Obesity, Cardiovascular Disease, Hypertension, Glucose Intolerance, And Abnormalities In Whole Body Metabolism. Presenting Essential Knowledge In The Field Of Insulin Resistance, This Book Will Benefit Clinicians, Pharmaceutical Scientists, And Researchers Involved In Endocrinology, Biochemistry And Metabolism In Diabetes. Insulin resistance is a key factor in the pathogenesis of obesity and type 2 diabetes, the world's most prevalent metabolic disorder.