Insulin - Like Growth Factors. Somatomedins : Basic Chemistry, Biology and Clinical Importance. Proceedings of a Symposium on Insulin-Like Growth Factors, Somatomedins, Nairobi, Kenya, November 13–15, 1982

Preface CONTENTS The Three Historical Origins of Insulin-Like Growth Factor Research THE SOMATOMEDIN HYPOTHESIS: ORIGINS AND RECENT DEVELOPMENTS FROM NSILA TO IGF: A LOOK BACK ON THE MAJOR ADVANCES AND BREAKTHROUGHS MULTIPLICATION STIMULATING ACTIVITY FOR CELLS IN CULTURE In Vivo Action of Insulin-Like Growth Factors LONG-TERM IN VIVO EFFECTS OF INSULIN-LIKE GROWTH FACTORS (IGF) I AND II ON GROWTH INDICES: DIRECT EVIDENCE IN FAVOR OF THE SOMATOMEDIN HYPOTHESIS 1 2 5I-IGF BINDING PATTERNS IN SERUM AND GLUCOSE TRANSPORT IN FAT CELLS FROM HYPOX RATS AFTER LONG-TERM TREATMENT WITH IGF I, IGF II OR GROWTH HORMONE (GH): EVIDENCE FOR EFFECTS OF GH NOT MEDIATED BY IGF INSULIN-LIKE GROWTH FACTORS: DIRECT CNS EFFECTS ON PULSATILE GROWTH HORMONE SECRETION AND BODY WEIGHT REGULATION THE SYNLACTIN HYPOTHESIS: PROLACTIN'S MITOGENIC ACTION MAY INVOLVE SYNERGISM WITH A SOMATOMEDIN-LIKE MOLECULE Structure and Purification of Insulin-Like Growth Factors THE IDENTITY OF HUMAN INSULIN-LIKE GROWTH FACTORS I AND II WITH SOMATOMEDINS C AND A AND HOMOLOGY WITH RAT IGF I AND II. A COMPUTER GRAPHICS STUDY OF INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTOR INTERACTIONS EVIDENCE FOR PROTEOLYTIC CONVERSION OF INSULIN-LIKE GROWTH FACTORS TO A BIOLOGICALLY ACTIVE ACIDIC FORM IGF-LIKE CHARACTERISTICS OF AN ACIDIC NON-SUPPRESSIBLE INSULIN-LIKE ACTIVITY SOMATOMEDIN-LIKE ACTIVITY IN BOVINE SERUM The Carrier Protein for Insulin-Like Growth Factors SERUM FORMS OF INSULIN-LIKE GROWTH FACTORS AND THEIR CARRIER PROTEINS CHARACTERIZATION OF THE IGF BINDING PROTEINS(BPs) PRODUCED BY THE LIVER IN ORGAN CULTURE. THEIR RELATIONS WITH SERUM BPs & CEREBROSPINAL FLUID BPs. A HUMAN HEPATOBLASTOMA-DERIVED CELL LINE (HEP G2) SECRETES A SPECIFIC IGF CARRIER PROTEIN Measurement of Insulin-Like Growth Factors DETERMINATION OF INSULIN-LIKE GROWTH FACTORS: A SURVEY OF METHODS THE USE OF SYNTHETIC PEPTIDES FOR THE DEVELOPMENT OF RADIOIMMUNOASSAYS FOR THE INSULIN-LIKE GROWTH FACTORS MEASUREMENT OF INSULIN-LIKE GROWTH FACTORS: SPECIAL CONSIDERATIONS RELATED TO BASIC SOMATOMEDIN IN SERUM Regulation of Plasma Levels of Insulin-Like Growth Factor Levels Regulation of Plasma Levels of Insulin-Like Growth Factor Levels UNDERNUTRITION AND INHIBITORS AS REGULATORS OF IGF PLASMA LEVELS AND CELLULAR ACTION THYMIDINE INHIBITORY ACTIVITY OF RAT SERUM: ITS INFLUENCE ON CORNEA AND CARTILAGE IN STARVED AND HYPOPHYSECTOMIZED RATS EFFECT OF COLD STRESS ON PLASMA SOMATOMEDIN ACTIVITY (SM) AND GROWTH IN RATS Clinical Uses of Plasma Insulin-Like Growth Factor Levels PLASMA IMMUNOREACTIVE SOMATOMEDIN-C/IGF I IN THE EVALUATION OF SHORT STATURE AGE RELATED VARIATIONS OF IGF (INSULIN-LIKE GROWTH FACTOR) AND IGF BP (IGF BINDING PROTEIN) SERUM LEVELS IN NORMAL CHILDREN AND ADOLESCENTS. COMPARISON WITH LEVELS IN CHILDREN WITH CONSTITUTIONAL SHORT STATURE SOMATOMEDIN ACTIVITY IN PATIENTS WITH GROWTH RETARDATION DUE TO HYPOPITUITARISM OR FAMILIAL-CONSTITUTIONAL GROWTH DELAY INSULIN-LIKE GROWTH FACTORS IN PYGMIES: CHARACTERIZATION OF THE METABOLIC ACTIONS OF IGF I AND IGF I I IN MAN SOMATOMEDINS IN THE AKA PYGMIES FROM "BASSE-LOBAYE" SOMATOMEDIN AND GH MEASUREMENTS IN ACROMEGALY COMPARISON OF SOMATOMEDIN C WITH GROWTH HORMONE LEVELS IN EVALUATING THERAPEUTIC RESPONSE IN TREATED ACROMEGALY PLASMA SOMATOMEDIN IN DIABETICS WITH RETINOPATHY AND JOINT CONTRACTURES INSULIN-LIKE GROWTH FACTORS IN ADULT DIABETICS EVOLUTION OF SERUM IGF (INSULIN-LIKE GROWTH FACTOR) LEVELS IN PATIENTS WITH INSULIN-DEPENDENT DIABETES DURING SEVERE KETOSIS AND REEQUILIBRATION IS C-PEPTIDE A MARKER FOR RETINAL ANGIOGENESIS FACTOR? THE ROLE OF SOMATOMEDINS IN PSYCHIATRIC DISORDERS INSULIN-LIKE GROWTH FACTOR (IGF) LEVELS MEASURED BY RADIOIMMUNOASSAY (RIA) AND RADIORECEPTORASSAY (RRA) IN VARIOUS FORMS OF TUMOR HYPOGLYCEMIA HYPOGLYCAEMIA IN PRIMARY HEPATOMA Insulin-Like Growth Factors in Fetal Growth and Development ROLE OF SOMATOME DINS/INSULIN—LIKE GROWTH FACTORS IN THE REGULATION OF FETAL GROWTH REDUCED PLASMA SOMATOMEDIN ACTIVITY DURING EXPERIMENTAL GROWTH RETARDATION IN THE FETAL AND NEONATAL RAT STIMULATION OF THYMIDINE INCORPORATION INTO FETAL RAT CARTILAGE IN VITRO BY HUMAN SOMATOMEDIN, EPIDERMAL GKOWffl FACTOR AND OTHER GROWTH FACTORS THE POTENTIAL OF INSULIN AS A REGULATOR OF FETAL SOMATOMEDIN PRODUCTION INCREASED SOMATOMEDIN ACTIVITY (SM) FOLLOWING CHRONIC HYPËRINSULINAEMIA IN PETAL PIGS SERUM GROWTH-PROMOTING ACTIVITY OF HUMAN NEWBORNS AND MOTHERS MEASURED AS 3H-THYMIDINE INCORPORATION INTO HUMAN ACTIVATED LYMPHOCYTES Biological Actions of Insulin-Like Growth Factors ROLE OF SOMATOMEDINS IN THE REGULATION OF THE ANIMAL CELL CYCLE IGF-EFFECTS ON AND BINDING TO RAT CALVARIA CELLS IN CULTURE ACTION OF GROWTH FACTORS ON CHONDROCYTES: DISCOVERY OF LOCAL SOMATOMEDINS IN FETAL BOVINE CARTILAGE MITOGENIC ACTION OF SOMATOMEDIN PEPTIDES ON HUMAN CARTILAGE AND CHONDROCYTES STIMULATION OF GLYCOGEN SYNTHESIS IN OSTEOBLAST-LIKE CELLS BY PTH AND IGF SERUM SOMATOMEDIN BIOACTIVITIES: INTERRELATIONS BETWEEN 35 SO 4 AND 3 H-THYMIDIIME UPTAKES IN CARTILAGE AND 3 H-THYMIDINE INCORPORATED IN ACTIVATED LIMPHOCYTES, IN CHICKEN AND HUMAN INSULIN AND SOMATOMEDIN C AS GROWTH PROMOTERS OF CELLS IN SERUM-FREE MEDIUM Receptors for Insulin-Like Growth Factors PROPERTIES OF INSULIN-LIKE GROWTH FACTOR RECEPTOR SUBTYPES RECEPTORS FOR INSULIN-LIKE GROWTH FACTORS: BASIC SOMATOMEDIN RECEPTORS IN HUMAN AND RODENT TISSUES REGULATION OF SOMATOMEDIN-C/INSULIN-LIKE GROWTH FACTOR-I RECEPTORS SOMATOMEDIN AND INSULIN RECEPTORS IN RAT CHONDROCYTES IGF-II RECEPTOR EXPRESSION IN DEVELOPING TISSUES: MODELS IN VIVO AND IN VITRO REGULATION OF BINDING OF INSULIN AND INSULINLIKE GROWTH FACTOR BY CELL GROWTH STATUS SOMATOMEDIN RECEPTORS IN THE HUMAN BRAIN THROUGHOUT LIFE Molecular Biology of Insulin-Like Growth Factors ECTOPIC GROWTH FACTOR PRODUCTION BY TUMOR CELLS AND THEIR ROLE IN THE EXPRESSION OF THE TRANSFORMED PHENOTYPE IMMUNOPEROXIDASE LOCALIZATION OF INSULIN-LIKE GROWTH FACTOR-I CONTAINING TISSUES PRODUCTION OF INSULIN-LIKE GROWTH FACTORS (IGFs) AND THEIR BINDINC PROTEINS (IGF BPs) BY THE PITUITARY GLAND AND THE NERVOUS TISSUE IN CULTURE MONOCLONAL ANTIBODIES THAT INHIBIT THE SULPHATION ACTIVITY OF HUMAN SERUM INTERACTIONS OF ULTRAFILTRABLE FACTORS PRESENT IN THE HUMAN SERUM WITH SOMATOMEDIN LIKE PEPTIDES SYNTHESIS AND SECRETION OF ITS BINDING PROTEIN BY THE GROWTH HORMONE STATUS INSULIN-LIKE GROWTH FACTOR AND OF PERFUSED RAT LIVER: DEPENDENCE OF INFLUENCE OF NUTRITION ON SOMATOMEDIN INSULIN-LIKE GROWTH FACTOR II SYNTHESIS AND RELEASE FROM CULTURED BUFFALO RAT LIVER CELLS BIOSYNTHESIS OF MULTIPLICATION STIMULATING ACTIVITY (MSA) IN RAT LIVER CELLS: DEMONSTRATION OF PRE-PRO-MSA AND PROMSA. PUBERTAL RISE OF IMMUNOREACTIVE SOMATOMEDIN AND ITS EVENTUAL SOURCE HIGH MOLECULAR WEIGHT SOMATOMEDIN-C/IGF-I FROM T47D HUMAN MAMMARY CARCINOMA CELLS: IMMUNOREACTIVITY AND BIOACTIVITY BIGUANIDES INHIBIT SOMATOMEDIN ACTION IN VITRO THE INSULIN (IGF) GENE FAMILY SUBJECT INDEX Author Index

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