Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics (Cancer Drug Discovery and Development Book 0)

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer. Front Matter....Pages i-xii Epidemiology of IGF-1 and Cancer....Pages 1-24 Aging and Cancer: The IGF-I Connection....Pages 25-36 Obesity, Type 2 Diabetes and Cancer....Pages 37-72 IGF System and Breast Cancer....Pages 73-84 The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression....Pages 85-103 IGF-1 Cellular Action and its Relationship to Cancer: Evidence from in Vitro and in Vivo Studies....Pages 105-146 Insulin-Like Growth Factor Signaling in Pediatric Sarcomas....Pages 147-158 Cancer Genes, Tumor Suppressors, and Regulation of IGF1-R Gene Expression in Cancer....Pages 159-177 Mouse Models of IGF-1R and Cancer....Pages 179-191 Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy....Pages 193-213 Targeting Insulin-Like Growth Factor Receptor 1 (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer....Pages 215-229 Calories and Cancer: The Role of Insulin-Like Growth Factor-1....Pages 231-243 Cancer Cell Metabolism....Pages 245-261 Overlaps Between the Insulin and IGF-I Receptor and Cancer....Pages 263-278 Back Matter....Pages 279-284 The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials Annotation This book explores the insulin-like growth factor system and its vital role in cancer development and progression. Topics covered include biology, epidemiology and the therapeutic potential of inhibiting receptors using newly discovered antibodies and kinase inhibitors This book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer