Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, Second Edition

Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism. The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature which has led to the need for this second edition. This second edition also: * Introduces many illustrations and colour photos to make the basic concepts far clearer * Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc * Provides additional anecdotes * Incorporates an extensive and up-to-date bibliography Content: Chapter 1 Solution Chemistry of Iron in Biological Media (pages 1–15): Chapter 2 The Importance of Iron for Biological Systems (pages 17–48): Chapter 3 Microbial Iron Uptake (pages 49–81): Chapter 4 Iron Uptake by Plants and Yeast (pages 83–105): Chapter 5 Cellular Iron Uptake in Mammals (pages 107–131): Chapter 6 Intracellular Iron Storage and Biomineralization (pages 133–165): Chapter 7 Intracellular Iron Metabolism and Cellular Iron Homeostasis (pages 167–190): Chapter 8 Iron Absorption in Mammals with Particular Reference to Man (pages 191–206): Chapter 9 Pathophysiology of Iron Deficiency and Iron Overload in Man (pages 207–233): Chapter 10 Iron and Oxidative Stress (pages 235–257): Chapter 11 Iron and Infection (pages 259–284): Chapter 12 Interactions between Iron and Other Metals (pages 285–312): Chapter 13 Concluding Remarks (pages 313–319):

Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well-established role in infections by a wide range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism.

The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of iron homeostasis. The application of molecular biological techniques to cellular biology of iron metabolism has resulted in a rapid expansion in the literature and has precipitated the need for this second edition.

Unlike the first edition this book is a collaboration between five authors providing expert knowledge in their individual specialist areas of research. Written, like the first edition, in a relaxed and humorous style, this new edition has many additional features including:

* use of illustrations - including extensive use of colour - to make basic concepts clearer

* a new chapter dealing with the interactions of iron with other metals particularly copper and zinc

* an extensive and up-to-date bibliography.

Inorganic Biochemistry of Iron Metabolism, Second Edition is both authoritative - author collaboration ensures coverage by specialists in a coherent manner and comprehensive - both fundamental concepts and applied aspects are covered. It will be essential reading for many researchers in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. These will include bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism and pharmacologists in the pharmaceutical industry interested in developing novel iron binding drugs.

Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well-established role in infections by a wide range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of iron homeostasis. The application of molecular biological techniques to cellular biology of iron metabolism has resulted in a rapid expansion in the literature and has precipitated the need for this second edition. Unlike the first edition this book is a collaboration between five authors providing expert knowledge in their individual specialist areas of research. Written, like the first edition, in a relaxed and humorous style, this new edition has many additional features including: • use of illustrations - including extensive use of colour - to make basic concepts clearer • a new chapter dealing with the interactions of iron with other metals particularly copper and zinc • an extensive and up-to-date bibliography. Inorganic Biochemistry of Iron Metabolism, Second Edition is both authoritative - author collaboration ensures coverage by specialists in a coherent manner and comprehensive - both fundamental concepts and applied aspects are covered. It will be essential reading for many researchers in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. These will include bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism and pharmacologists in the pharmaceutical industry interested in developing novel iron binding drugs.rgy. This volume explores the chemistry, biology, biochemistry, physiology and medical aspects of iron in biological systems from microorganisms to man. This second edition includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc. Iron, element 26 in the periodic table, is the second most abundant metal (after aluminum) and the fourth most abundant element of the earth's crust.