Inorganic and Nutritional Aspects of Cancer : Proceedings of the First Conference of the International Association of Bioinorganic Scientists, Inc. Held in La Jolla, California, January 3–5, 1977

For many decades, cancer research concentrated heavily on "or­ ganic" aspects of the disease and ignored the role of trace elements and minerals in carcinogenesis and tumor growth. However, in recent years, spectacular progress has been made in "inorganic" cancer research: numerous inorganic substances were shown to possess car­ cinogenic properties. Quite unexpectedly, certain coordination compounds of platinum were found to have powerful antineoplastic properties, and a number of essential trace elements were demon­ strated to have profound effects on the genesis and growth of spontaneous, induced, or transplanted tumors. It therefore appeared desirable to call upon leading authorities in the field of inorganic cancer research to present their views in a conference dedicated specifically to their discipline. But since trace elements are nor­ mal constituents of foods, it seemed advantageous to include nutri­ tional aspects into the program. The fact that diet and nutrition influence tumor growth and development has been known or suspected for a long time. However, too little research has been done in this important field, resulting in a serious retardation of knowledge. Hence, this opportunity to cover nutritional aspects of cancer was taken, even though it was clear from the beginning that this broad field could not really be treated in the available time. It was necessary, for example, to exclude entirely the vast area of nutri­ tion as an adjuvant in cancer therapy, and even then, further limi­ tation of the scope of topics to be covered had to be made. Front Matter....Pages i-xi Front Matter....Pages xiii-xiii An Overview of Metal Carcinogenesis....Pages 1-12 Beryllium Carcinogenesis....Pages 13-27 Asbestos Carcinogenesis....Pages 29-55 Carcinogenicity of Nickel Subsulfide in Fischer Rats and Syrian Hamsters after Administration by Various Routes....Pages 57-67 The Topical Effects of Nickel Subsulfide on Renal Parenchyma....Pages 69-83 Lung Tumor Response in Mice to Metals and Metal Salts....Pages 85-91 Occupational Cancer in Men Exposed to Metals....Pages 93-102 Infidelity of DNA Synthesis as Related to Mutagenesis and Carcinogenesis....Pages 103-115 Metals as Mutagens....Pages 117-128 Front Matter....Pages N1-N1 Noble Metal Complexes in Cancer Chemotherapy....Pages 129-150 Potential Carcinostatic Activity of Metal Complexes....Pages 151-160 Anti-Tumor Virus Activity of Copper-Binding Drugs....Pages 161-178 Reaction of Copper Complexes with Ehrlich Cells....Pages 179-191 The Inhibitory Effect of Copper on Ethionine Carcinogenesis....Pages 193-206 Front Matter....Pages N2-N2 Diet, Nutrition, and Cancer....Pages 207-228 The Effects of Iron Deficiency and the Quality and Quantity of Fat on Chemically Induced Cancer....Pages 229-242 Implications of the Inhibition of Animal Tumors by Dietary Zinc Deficiency....Pages 243-257 The Arsenic Problems....Pages 259-279 The Influence of Nutritional Factors on Pulmonary Adenomas in Mice....Pages 281-292 Iodine and Mammary Cancer....Pages 293-304 Front Matter....Pages N2-N2 Gastrointestinal Cancer: Epidemiology and Experimental Studies....Pages 305-322 Front Matter....Pages N3-N3 Trace Elements, Nutrition and Cancer: Perspectives of Prevention....Pages 323-344 Back Matter....Pages 345-351