Innovative Approaches to Cell Biomechanics: From Cell Migration to On-Chip Manipulation (Frontiers of Biomechanics Book 1)

This book covers topics on mechanosensing, mechanotransduction, and actin cytoskeletal dynamics in cell motility. It will contribute to a better understanding of how cells functionally adapt to their mechanical environment as well as highlighting fundamental concepts for designing material niches for cell manipulation. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, the book is the first of its kind, providing comprehensive, integrated coverage of innovative approaches to cell biomechanics. It provides a valuable resource for seniors and graduate students studying cell biomechanics, and is also suitable for researchers interested in the application of methods and strategies in connection with the innovative approaches discussed. Each section of the book has been supplemented with concrete examples and illustrations to facilitate understanding even for readers unfamiliar with cell biomechanics Front Matter....Pages i-xiv Introduction to Actin-Based Cell Migration....Pages 1-10 Regulation of Actin Cytoskeleton Dynamics in Migrating Cells....Pages 11-25 Actin Network Flow and Turnover Are Coupled in Migrating Cells....Pages 27-39 Involvement of Mechanical Strain in Actin Network Reorganization....Pages 41-56 Regulation of Actin Network Dynamics by Actomyosin Contractility....Pages 57-72 Multiscale Analysis of Cell Peripheral Motility....Pages 73-86 Multiscale Mechanochemical Interactions Between Cell Membrane and Actin Filaments....Pages 87-105 Actomyosin Contractility Modulates Lamellipodial Protrusion Dynamics on a Micropatterned Substrate....Pages 107-121 Cell Migration on Engineered Microstructured Surfaces....Pages 123-138 Cell Migration in Engineered Microstructured Surfaces....Pages 139-158 Design Concept of Topographical and Mechanical Properties of Synthetic Extracellular Matrix to Control Cell Functions and Fates Through Actin Cytoskeletal Modulation....Pages 159-186 Back Matter....Pages 187-190