Innovative approaches in drug discovery : ethnopharmacology, systems biology, and holistic targeting

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. __Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting__ provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is nowfor a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. * Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned * Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines * Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.

• Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned
• Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines
• Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Despite Considerable Technological Advances, The Pharmaceutical Industry Is Experiencing A Severe Innovation Deficit, Especially In The Discovery Of New Drugs. Innovative Approaches In Drug Discovery: Ethnopharmacology, Systems Biology And Holistic Targeting Provides A Critical Review And Analysis Of Health, Disease And Medicine, And Explores Possible Reasons Behind The Present Crisis In Drug Discovery. The Authors Illustrate The Benefits Of Systems Biology And Pharmacogenomics Approaches, And Advocate The Expansion From Disease-centric Discovery To Person-centric Therapeutics Involving Holistic, Multi-target, Whole Systems Approaches. This Book Lays A Path For Reigniting Pharmaceutical Innovation Through A Disciplined Reemergence Of Pharmacognosy, Embracing Open Innovation Models And Collaborative, Trusted Public-private Partnerships. With Unprecedented Advances Made In The Development Of Biomedically-relevant Tools And Technologies, The Need Is Great And The Time Is Now For A Renewed Commitment Towards Expanding The Repertoire Of Medicines.ïÅư By Incorporating Real-life Examples And State-of-the-art Reviews, This Book Provides Valuable Insights Into The Discovery And Development Strategies For Professionals, Academicians, And Students In The Pharmaceutical Sciences. Bhushan Patwardhan, Phd, Fams, Rathnam Chaguturu, Phd. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines.ïÅ{u00BD} By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines.ïÅ1⁄2 By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences Content: Front-matter,Copyright,About the Editors,About the Authors,Foreword,Preface,DedicationEntitled to full textChapter 1 - Drug Discovery Impasse: Pharmacognosy Holds the Key, Pages 1-22 Chapter 2 - Why and How Drugs Fail, Pages 23-64 Chapter 3 - Holistic Drug Targeting, Pages 65-88 Chapter 4 - Reverse Pharmacology, Pages 89-126 Chapter 5 - Network Pharmacology, Pages 127-164 Chapter 6 - Genomics-Driven Drug Discovery Process, Pages 165-194 Chapter 7 - Pharmacogenomics, Pages 195-234 Chapter 8 - Transcriptomics and Epigenomics, Pages 235-272 Chapter 9 - Proteomics, Pages 273-294 Chapter 10 - Chemical Informatics, Pages 295-314 Chapter 11 - Vaccines and Immunodrugs Discovery, Pages 315-341 Chapter 12 - Curcumin, the Holistic Avant-Garde, Pages 343-349 Chapter 13 - Safety of Traditional Medicines, Pages 351-365 Chapter 14 - Holistic Lifestyle, Pages 367-385 Chapter 15 - Collaborative Strategies for Future Drug Discovery, Pages 387-410 Chapter 16 - Righting the Ship: The Data Reproducibility Conundrum, Pages 411-427 Index, Pages 429-442