Innovation in Vaccinology : From Design, Through to Delivery and Testing

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science. "Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may be ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. The common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the 'melting pot', expertise in fields that at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction and ceasing to be an empirical science."--Publisher's description Front Matter....Pages i-xii Front Matter....Pages 1-1 Design of New Vaccines in the Genomic and Post-genomic Era....Pages 3-15 Comparing In Silico Results to In Vivo and Ex Vivo of Influenza-Specific Immune Responses After Vaccination or Infection in Humans....Pages 17-42 Front Matter....Pages 43-43 Virus Glycoproteins Tagged with the Human Fc Domain as Second Generation Vaccine Candidates....Pages 45-63 Engineered Viruses as Vaccine Platforms....Pages 65-86 Virus-Like Particles as Efficient Delivery Platform to Induce a Potent Immune Response....Pages 87-122 Filamentous Bacteriophages: An Antigen and Gene Delivery System....Pages 123-134 Liposomes and Other Nanoparticles as Cancer Vaccines and Immunotherapeutics....Pages 135-178 Plant-Based Vaccine Delivery Strategies....Pages 179-203 TLR Agonists as Vaccine Adjuvants....Pages 205-228 Mucosal Vaccines for Enteric Bacterial Pathogens....Pages 229-248 Front Matter....Pages 249-249 The Importance of Animal Models in the Development of Vaccines....Pages 251-264 Correlates of Vaccine-Induced Immunity: Historical Perspectives and Future Challenges....Pages 265-285 Back Matter....Pages 287-288