Innate immunity resistance and disease-promoting principles ; [Ilse-Kröner-Fresenius-Symposium in May 2012

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity. Microbiota's influence on immunity / Honda, K. ... [et al.] Inflammasomes and mucosal immune response / Elinav, E., Henao-Mejia, J., Flavell, R.A. Microbial endocrinology : an evolution-based shared mechanism determining microbiota's influence on health and disease / Lyte, M. Standing guard : innate lymphoid cells promote immunity and tissue homeostasis at barrier surface / Monticelli, L.A., Artis, D. miRNAs that shape the innate immune system : regulation through toll-like receptor signaling / Curtis, A.M., O'Neill, L.A. Type 2 diabetes and islet inflammation / Donath, M.Y. The innate immune system in Alzheimer's disease / Becker, H., Halle, A. Role of inflammasomes in obesity / Dixit, V.D. Gut-brain communication in the regulation of system metabolism / Miller, T.D., Pfliger, P.T., and Tschip, M.H. Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in drosophila / Loch, G. ... [et al.] Dendritics cells orchestrate innate immunity agains bacterial kidney infection / Tittel, A.P. ... [et al.].