Inhibition of Polyamine Metabolism : Biological Significance and Basis for New Therapies

Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis inhibitors. The book is comprised of chapters which describe the compounds which are in use; the rationale for the design of such inhibitors; their synthesis and action; their biological effects on mammalian cells and tissues, plants, and microorganisms including protozoal parasites; and a review of the clinical experience with these inhibitors. The major beneficial effect which the wide availability of these inhibitors has had on the field of polyamine research in general is likewise demonstrated. Biochemists, pharmacologist, and cellular physiologists will find this text very useful. Content: Front Matter , Page iii Copyright , Page iv Preface , Pages xi-xii , Peter P. McCann, Anthony E. Pegg, Albert Sjoerdsma Introduction: Polyamine Metabolism , Pages xiii-xvi , Peter P. McCann, Anthony E. Pegg, Albert Sjoerdsma 1 - Inhibition of Basic Amino Acid Decarboxylases Involved in Polyamine Biosynthesis , Pages 1-31 , PHILIPPE BEY, CHARLES DANZIN, MICHEL JUNG 2 - Pharmacologic Interference with Enzymes of Polyamine Biosynthesis and of 5′-Methylthioadenosine Metabolism , Pages 33-48 , ANTHONY E. PEGG, H. GUY WILLIAMS-ASHMAN 3 - Inhibition of Enzymes Oxidizing Polyamines , Pages 49-77 , N. SEILER 4 - Molecular and Cellular Functions of the Polyamines , Pages 79-105 , LAURENCE J. MARTON, DAVID R. MORRIS 5 - The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake , Pages 107-119 , ANTHONY E. PEGG 6 - Inhibitors of Polyamine Biosynthesis: Cellular and in Vivo Effects on Tumor Proliferation , Pages 121-140 , PRASAD S. SUNKARA, STEPHEN B. BAYLIN, GORDON D. LUK 7 - Polyamine Inhibition in Vivo and in Organ Growth and Repair , Pages 141-164 , CHARLES DANZIN, PIERRE S. MAMONT 8 - Polyamine Synthesis Inhibitors Act as both Inducers and Suppressors of Cell Differentiation , Pages 165-186 , OLLE HEBY, GORDON D. LUK, JOEL SCHINDLER 9 - The Contragestational Effects of Ornithine Decarboxylase Inhibition , Pages 187-202 , J.R. FOZARD 10 - Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis , Pages 203-248 , CARL W. PORTER, JUHANI JÄNNE 11 - Inhibition of Carcinogenesis by Inhibitors of Putrescine Biosynthesis , Pages 249-258 , AJIT K. VERMA, R.K. BOUTWELL 12 - Inhibition of Polyamine Biosynthesis in Microorganisms , Pages 259-275 , ALAN J. BITONTI, PETER P. MCCANN 13 - Inhibition of Viral Polyamine Biosynthesis , Pages 277-304 , A. STANLEY TYMS, JOHN D. WILLIAMSON 14 - Inhibition of Polyamine Biosynthesis in Plants and Plant Pathogenic Fungi , Pages 305-316 , ROBERT D. SLOCUM, ARTHUR W. GALSTON 15 - Parasitic Protozoa and Polyamines , Pages 317-344 , CYRUS J. BACCHI, PETER P. McCANN 16 - Clinical Aspects of Inhibition of Ornithine Decarboxylase with Emphasis on Therapeutic Trials of Eflornithine (DFMO) in Cancer and Protozoan Diseases , Pages 345-364 , PAUL J. SCHECHTER, JOHN L.R. BARLOW, ALBERT SJOERDSMA Index , Pages 365-371