Inhalation Anaesthesia Today And Tomorrow (anaesthesiologie Und Intensivmedizin Anaesthesiology And Intensive Care Medicine)

In clinical anaesthesiology the inhalation anaesthetics halothane (fluothane), enflurane and - in recent times - forane got a renaissance in clinical application. The reasons are not only the ad­ vantages of volatile anaesthetics, but also the fact that the investi­ gations of pharmacodynamics and pharmacokinetics of Lv. narcot­ ics showed negative aspects. It was the aim of the organizers of the symposium to give a survey of the present state of knowledge on inhalation anaesthetics, which is as up-to-date, critical as well as detailed as possible. Furthermore it was the intention to evaluate the recent advances made in the field of basic research. The first section of the symposium in particular enters into the question of the toxicity of volatile anaesthetics as well as their mechanisms of action. In a second main part the influences on cardiovascular system and on microcirculation are discussed. Apart from the extensive discussion of the advances in knowledge in the field of cardiovascular pathophysiology, the focal point of the contribut­ ions is made up of those with anaesthesia in coronary heart disease and cardiac insufficieny as well as the contribution on interactions of inhalation anaesthetics with cardiovascular drugs. In the third and fourth section the influences of volatile anaesthetics on cerebral, hepatic, renal and pulmonary function are dealt with as well as questions concerning the clinical application. Particular attention is given to the important problems of indicat­ ion in patients belonging to the extreme age groups. Front Matter....Pages I-XII Basics of Biotransformation....Pages 1-10 Hepatic Oxygenation and Fluoride Release During Halothane Anesthesia....Pages 11-12 Current Status of Hepatotoxicity of the Halogenated Inhalation Anesthetics....Pages 13-18 Present Status of Chronic Exposure to Trace Concentrations of Volatile Anaesthetics....Pages 19-25 Aspects of Possible Health Hazards from Traces of Waste Anaesthetic Vapours and Gases....Pages 27-29 The Kinetics of the Uptake and Elimination of Halothane and Enflurane....Pages 31-44 Molecular Basis for Unitary Theories of Inhalation Anaesthesia....Pages 45-52 Clinical Implications of the Pharmacodynamics of Inhalation Anaesthetics....Pages 53-58 Advances in Cardiovascular Pathophysiology....Pages 59-77 Anaesthesia in Coronary Heart Disease....Pages 79-85 The Anaesthetic Management of Coronary and Cardiac Surgery....Pages 87-95 Influence of Inhalation Anaesthetics on the Autonomic Nervous System....Pages 97-108 Interactions of Cardiovascular Drugs with Inhalational Anaesthetics....Pages 109-128 Microcirculatory Effects of Halothane and Enflurane....Pages 129-135 Distribution of EEG Frequency Bands as Revealed by Factor Analysis During Anaesthesia with Halothane and Enflurane....Pages 137-146 The Effects of Inhalational Anaesthetics on the Brain....Pages 147-150 The Effects of Inhalation Anaesthetics on Intracranial Pressure....Pages 151-157 The Effects of Inhalation Anaesthetic Agents on Liver Blood Flow and Hepatic Oxygen Consumption....Pages 159-163 Total Effect of Repeated Anaesthetics on Liver Function....Pages 165-166 The Effect of Inhalation Anaesthetics on Pulmonary Ventilation and Perfusion....Pages 167-176 Effects of Inhalation Anaesthetics on Renal Function A Brief Review with Special Reference to Renal Handling of Fluoride Ions....Pages 177-181 The Effect of Inhalation Anaesthetics on Skeletal and Smooth Muscle....Pages 183-186 Inhalation Anaesthesia and Endocrine Disease....Pages 187-203 Concept in Patients with Hypertension and Coronary Heart Disease — Clinical and Experimental Aspects....Pages 205-218 Inhalation Anaesthetics as Hypotensive Agents: Controversial Aspects....Pages 219-231 Inhalation Anaesthesia in Paediatrics....Pages 233-237 Inhalation Anaesthesia in Geriatric Patients....Pages 239-246 Balanced Anaesthesia as an Alternative Concept....Pages 247-250 Back Matter....Pages 251-259 Edited By K. Peter And F. Jesch. Includes Bibliographical References And Index.