Inflammatory Disorders Of The Nervous System: Pathogenesis, Immunology, And Clinical Management (current Clinical Neurology)

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders. Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide. Endothelial cell-leukocyte interactions during CNS inflammation / J. Steven Alexander and Alireza Minagar Interactions of the CNS and immune system / Monica J. Carson, Crystal S. Anglen, and Corinne Ploix Cytokines and brain : health and disease / Tammy Kielian and Paul D. Drew Chemokines and central nervous system disorders / William J. Karpus Circulating cell-derived microparticles in thrombotic and inflammatory disorders / Wenche Jy ... [et al.] Multiple sclerosis : clinical features, immunopathogenesis, and clinical management / William A. Sheremata Neuroprotective effects of interferon-b in multiple sclerosis / Fabrizio Giuliani, Rana Zabad, and V. Wee Yong Acute disseminated encephalomyelitis / Sean J. Pittock and Dean M. Wingerchuk Ingested type interferon in experimental autoimmune encephalomyelitis / Staley A. Brod Neuromyelitis optica / Dean M. Wingerchuk Transverse myelitis : clinical manifestations, pathogenesis, and management / Douglas A. Kerr ... [et al.] Optic neuritis : pathogenesis, immunology, and clinical management / Rohit Bakshi and Robert Zivadinov Central nervous system vasculitis : pathogenesis, immunology, and clinical management / Shariq Mumtaz ... [et al.] Neurosarcoidosis : pathogenesis, immunology, and clinical management / Dakshinamurty Gullapalli and Lawrence H. Phillips II Neuropsychiatric SLE : pathogenesis, immunology, and clinical management / Deborah Aleman-Hoey and Robin Brey Gene expression in HIV-associated dementia / Paul Shapshak ... [et al.] Human T-lymphotropic virus-associated neurological disorders : pathogenesis, immunology, and clinical treatment / Michael Lairmore ... [et al.] West Nile virus infection of the nervous system : pathogenesis, immunology, and clinical management / Douglas J. Lanska. A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

advances In Understanding Molecular Mechanisms Involved In Inflammatory Responses Active In Known Immune-mediated Neurological Disorders Such As Multiple Sclerosis And Lupus Are Being Extended To Treat Alzheimer's, Parkinson's, And Other Neurodegenerative Diseases. Thus Minegar And Alexander (louisiana State U. Health Center, Shreveport) Introduce 18 Chapters Reviewing Findings, New Concepts (e.g. Leukocyte Microparticles), And New Methodologies (e.g. Gene Microarray Technologies) Emerging From Research On Neuroinflammation. Contributors Also Describe Disorders In Which The Inflammatory Role Is Not Well Understood (e.g., Hiv-associated Dementia). Completion Of The Included Test Can Count For Continuing Medical Education Credit. Annotation ©2005 Book News, Inc., Portland, Or

"In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes." --Résumé de l'éditeur This is a cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute diss