Inflammatory Bowel Diseases : Proceedings of the International Symposium on Inflammatory Bowel Diseases, Jerusalem September 7–9, 1981

An international symposium on inflammatory bowel diseases was held in Jerusalem on September 7th-9th, 1981. The symposium was sponsored by the Hebrew University-Hadassah Medical SchooL and the Israeli Gastroenterological Society. The idea was to bring together leading workers in the field, to invite all those interested to present their new work on IBD and thus to enable exchange of information and cross­ fertilization needed to improve our understanding and handling of these diseases. The symposium was organized into four panels devoted to state of the art reviews. presentation of new findings and approaches on the follow­ ing topics: New pathological concepts. etiology. pathogenesis and management of IBD. In addition. 89 abstracts were presented as posters during the symposium. all of which were published in the book of abstracts. The concluding panel outlined new directions for future research on IBD. We owe our gratitude to Drs. J. B. Kirsner, G. L. Gitnick and C. E. Rubin, members of the Organizing Committee, without whose encouragement and help the symposium could not have taken place. The Organizing Committee owes a considerable debt of gratitude to all the contributors who presented their work in a clear and concise manner, to all those who presented posters and to all the participants who came from 27 countries. Their stimulating presentations and discussions con­ tributed to the success of the meeting. Front Matter....Pages I-X Front Matter....Pages 1-1 Pathologic Aspects of Diagnosis, Pathogenesis, and Etiology of Idiopathic Inflammatory Bowel Disease....Pages 3-18 Epithelioid Granuloma and Related Histologic Features Which May Differentiate Crohn’s Disease from Ulcerative Colitis in Rectal Biopsies....Pages 19-26 Dysplasia and Carcinoma in Inflammatory Bowel Disease....Pages 27-40 Athymic Nude Mice in Studies of Crohn’s Disease....Pages 41-55 Front Matter....Pages 57-57 Inflammatory Bowel Disease — The Search for an Etiology....Pages 59-67 Idiopathic Inflammatory Bowel Disease (IBD): A Review of Immunological Mechanisms....Pages 68-79 Ulcerative Colitis: An Autoimmune Disease?....Pages 80-95 Bacterial Etiology of Inflammatory Bowel Disease....Pages 96-109 Cytotoxic Inducers in Crohn’s Disease and Ulcerative Colitis....Pages 110-125 Animal Models for Human Inflammatory Bowel Diseases....Pages 126-134 Front Matter....Pages 135-135 Newer Concepts of IBD Epidemiology....Pages 137-142 Epidemilogy of Inflammatory Bowel Disease. State of the Art and Etiologic Inferences....Pages 143-151 Genetics and Inflammatory Bowel Disease....Pages 152-160 Possible Role of Prostanoids as Mediators in the Pathogenesis of Inflammatory Bowel Disease....Pages 161-173 Prostaglandins and the Mode of Action of Sulphasalazine in Ulcerative Colitis: Two Opposing Viewpoints....Pages 174-189 Pathogenesis of Diarrhea in Inflammatory Bowel Disease....Pages 190-203 Psychiatric Illness and Inflammatory Bowel Disease....Pages 204-212 Front Matter....Pages 213-213 Introduction....Pages 215-216 Colonoscopy in Inflammatory Bowel Disease....Pages 217-234 Drug Therapy of Inflammatory Bowel Disease....Pages 235-243 Front Matter....Pages 213-213 Total Parenteral Nutrition (TPN) in Inflammatory Bowel Disease....Pages 244-253 Ulcerative Colitis and Crohn’s Disease in Children....Pages 254-268 Surgical Management....Pages 269-281 Front Matter....Pages 283-283 Inflammtory Bowel Disease — New Directions for Future Research....Pages 285-290 New Directions for Medical Research in Inflammatory Bowel Disease....Pages 291-300 New Directions for Future Research:Surgical/Clinical....Pages 301-308 The study of disease entities as complex as Crohn's dis­ ease will increasingly require comprehensive knowledge of formerly unrelated areas of the medical sciences. To promote this broad approach, a conference was organized in which geneticists, morphologists, immunologists, and virologists participated as well as clinicians whose work is focused on Crohn's disease. Ample time was given to the presentation of major new findings in each of these areas, and comments were given by the participants in the various sections. This approach yielded many new ideas, because indiv iduals with very different backgrounds were able to address old problems from fresh angles. This volume, published in January, 1981, contains the papers presented dur ing the wor kshop held in June, 1980, in Noordwijk/Leiden, The Netherlands. In addition, we have in­ cluded the extensive discussions, edited by experts in the field, which followed each presentation. Finally, each main category is followed by a summary of the topic covered as well as many valuable conclusions concerning the significance of recent work and ideas for new directions in research. In the Preface, J.B. Kirsner gives a comprehensive review of the material, and in an Afterword A.J.Ch. Haex deals with a num­ ber of other aspects. We believe that this volume will be of value to a wide spectrum of scientists and clinicians and that it will help to establ ish the mul tid isciplinary approach to Crohn's dis­ ease as the one that should predominate in the future. An international symposium on inflammatory bowel diseases was held in Jerusalem on September 7th-9th, 1981. The symposium was sponsored by the Hebrew University-Hadassah Medical SchooL and the Israeli Gastroenterological Society. The idea was to bring together leading workers in the field, to invite all those interested to present their new work on IBD and thus to enable exchange of information and crossƯ fertilization needed to improve our understanding and handling of these diseases. The symposium was organized into four panels devoted to state of the art reviews. presentation of new findings and approaches on the followƯ ing topics: New pathological concepts. etiology. pathogenesis and management of IBD. In addition. 89 abstracts were presented as posters during the symposium. all of which were published in the book of abstracts. The concluding panel outlined new directions for future research on IBD. We owe our gratitude to Drs. J.B. Kirsner, G.L. Gitnick and C.E. Rubin, members of the Organizing Committee, without whose encouragement and help the symposium could not have taken place. The Organizing Committee owes a considerable debt of gratitude to all the contributors who presented their work in a clear and concise manner, to all those who presented posters and to all the participants who came from 27 countries. Their stimulating presentations and discussions conƯ tributed to the success of the meeting The liver has been an organ of mystery for centuries. Slowly but surely its secrets have been disclosed by both basic research and clinically oriented investigators whose current concepts have been brought together in this book by authors from five different countries. Three major groups with many subgroups have made inroads into our better understanding of the liver. The first of these comprises the basic scientists whose study of single hepatocytes may provide the key to comprehension of mechanisms that will lead eventually to improvement in the morbidity and mortality associated with a variety of hepatic disorders. The second group has been concerned with studies in depth of the liver's response to a variety of hormones, drugs, viruses, and infections. Both early and late results are their concern in the diagnosis and treatment of the individual patient. A third group comprises the surgeons who have become increasingly aggressive in the removal of one or more segments of the liver. They have increased the scope of hepatic resection as a result of a better understanding gained from studies of various segments of the liver. They have accepted the term, segmentectomy, and have extended feasible procedures to include trisegmentectomy. Indeed, trans­ plantation of the liver has been successfully accomplished.