Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy (Subcellular Biochemistry) (Subcellular Biochemistry)

From the reviews: “This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. ... Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. ... It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.” (Vladimir N. Despotovic, Doody’s Review Service, February, 2010)

In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents.

Doody Review Services

Reviewer:Vladimir N Despotovic, MD(Washington University Medical Center)
Description:This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition.
Purpose:The purpose is to discuss in detail the current understanding of the role of inflammation in several common chronic diseases as well as the role of COX-2 and COX-2 related molecular targets and its inhibition with the current and future generations of anti-inflammatory drugs.
Audience:Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. It is written by a panel of distinguished authors who contribute in their areas of research and expertise.
Features:This is a methodical review of the current understanding of inflammation on a molecular and clinical level in multiple disorders, including obesity, cancer, cardiovascular disease, inflammatory arthritis, and neurodegenerative disease with a particular emphasis on COX-2, its role, and its inhibition. A special section details COX-2 inhibitors and their cardiovascular effects. The greatest strength of this book is its exhaustive literature review and its fluid integration into a coherent unit. Historical perspective is often provided and the book concludes with new trends in nutrition research including polyunsaturated fatty acids and flavonoids and their effect on inflammation. Its limitations are the limited illustrations and fairly short index.
Assessment:This book presents expertly written, consolidated current research in certain aspects of inflammation. It covers both the basic science and clinical aspects of inflammation with an emphasis on COX-2 and related molecular targets. It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.

978-1-4020-5688-8_BookFrontMatter_OnlinePDF.pdf 1 Inflammation in the Pathogenesis of Chronic Diseases 1 Contents 6 Preface 8 Contributors 9 Copy of 978-1-4020-5688-8_1_Part_OnlinePDF.pdf 12 SECTIONI Historical Perspectives 12 978-1-4020-5688-8_1_OnlinePDF.pdf 13 SECTIONI Historical Perspectives 1 Anti-Inflammatory Drugs in the 21st Century 13 Rainsford 13 Copy of 978-1-4020-5688-8_2_Part_OnlinePDF.pdf 38 SECTIONII Inflammatory Mechanisms of Pathogenesis 38 978-1-4020-5688-8_2_OnlinePDF.pdf 39 SECTIONII Inflammatory Mechanisms of Pathogenesis 1 Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus 39 Weinberg et al. 39 978-1-4020-5688-8_3_OnlinePDF.pdf 71 Obesity, Inflammation, and Vascular Disease 71 Calabro and Yeh 71 978-1-4020-5688-8_4_OnlinePDF.pdf 100 Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer 100 Harris 100 978-1-4020-5688-8_5_OnlinePDF.pdf 134 Role of COX-2 in Inflammatory and Degenerative Brain Diseases 134 Luisa Minghetti 134 Copy of 978-1-4020-5688-8_3_Part_OnlinePDF.pdf 149 SECTIONIII Inflammation and CardiovascularDisease: The coxib controversy 149 978-1-4020-5688-8_6_OnlinePDF.pdf 150 SECTIONIII Inflammation and CardiovascularDisease: The coxib controversy 1 Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors 150 White 150 978-1-4020-5688-8_7_OnlinePDF.pdf 164 COX-2 Inhibitors And CardiovascularRisk 164 Salzberg and Weir 164 978-1-4020-5688-8_8_OnlinePDF.pdf 180 A Biological Rationale for the Cardiotoxic Effects of Rofecoxib 180 Mason et al. 180 Copy of 978-1-4020-5688-8_4_Part_OnlinePDF.pdf 196 SECTIONIV COX-2 Blockade in Cancer Prevention and Therapy 196 978-1-4020-5688-8_9_OnlinePDF.pdf 197 SECTIONIV COX-2 Blockade in Cancer Prevention and Therapy 1 Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade 197 Harris et al. 197 978-1-4020-5688-8_10_OnlinePDF.pdf 217 Strategies for Colon Cancer Prevention 217 Reddy 217 Copy of 978-1-4020-5688-8_5_Part_OnlinePDF.pdf 230 SECTIONV Inflammation and Neurodegenerative Disease 230 978-1-4020-5688-8_11_OnlinePDF.pdf 231 SECTIONV Inflammation and Neurodegenerative Disease 1 NSAID1s for the Chemoprevention of Alzheimer's Disease 231 Szekely et al. 231 978-1-4020-5688-8_12_OnlinePDF.pdf 251 Inflammation in parkinson's disease 251 Hald et al. 251 Copy of 978-1-4020-5688-8_6_Part_OnlinePDF.pdf 282 SECTIONVI Nutrition, inflammation and Chronic Disease 282 978-1-4020-5688-8_13_OnlinePDF.pdf 283 SECTIONVI Nutrition, inflammation and Chronic Disease 1 Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases 283 Lorgeril 283 978-1-4020-5688-8_14_OnlinePDF.pdf 298 Nutritional Intervention in Brain Aging 298 Lau et al. 298 978-1-4020-5688-8_BookBackMatter_OnlinePDF.pdf 318 Front Matter....Pages 1-1 Anti-Inflammatory Drugs in the 21st Century....Pages 3-27 Front Matter....Pages 29-29 Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus....Pages 31-62 Obesity, Inflammation, and Vascular Disease....Pages 63-91 Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer....Pages 93-126 Role of COX-2 in Inflammatory and Degenerative Brain Diseases....Pages 127-141 Front Matter....Pages 143-143 Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors....Pages 145-158 COX-2 Inhibitors And Cardiovascular Risk....Pages 159-174 A Biological Rationale for the Cardiotoxic Effects of Rofecoxib....Pages 175-190 Front Matter....Pages 191-191 Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade....Pages 193-212 Strategies for Colon Cancer Prevention....Pages 213-225 Front Matter....Pages 227-227 NSAIDs for the Chemoprevention of Alzheimer’s Disease....Pages 229-248 Inflammation in parkinson’s disease....Pages 249-279 Front Matter....Pages 281-281 Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases....Pages 283-297 Nutritional Intervention in Brain Aging....Pages 299-318 In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.