Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy (Subcellular Biochemistry Book 42)

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents.

Doody Review Services

Reviewer:Vladimir N Despotovic, MD(Washington University Medical Center)
Description:This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition.
Purpose:The purpose is to discuss in detail the current understanding of the role of inflammation in several common chronic diseases as well as the role of COX-2 and COX-2 related molecular targets and its inhibition with the current and future generations of anti-inflammatory drugs.
Audience:Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. It is written by a panel of distinguished authors who contribute in their areas of research and expertise.
Features:This is a methodical review of the current understanding of inflammation on a molecular and clinical level in multiple disorders, including obesity, cancer, cardiovascular disease, inflammatory arthritis, and neurodegenerative disease with a particular emphasis on COX-2, its role, and its inhibition. A special section details COX-2 inhibitors and their cardiovascular effects. The greatest strength of this book is its exhaustive literature review and its fluid integration into a coherent unit. Historical perspective is often provided and the book concludes with new trends in nutrition research including polyunsaturated fatty acids and flavonoids and their effect on inflammation. Its limitations are the limited illustrations and fairly short index.
Assessment:This book presents expertly written, consolidated current research in certain aspects of inflammation. It covers both the basic science and clinical aspects of inflammation with an emphasis on COX-2 and related molecular targets. It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.

978-1-4020-5688-8_BookFrontMatter_OnlinePDF.pdf Inflammation in the Pathogenesis of Chronic Diseases Contents Preface Contributors Copy of 978-1-4020-5688-8_1_Part_OnlinePDF.pdf SECTIONI Historical Perspectives 978-1-4020-5688-8_1_OnlinePDF.pdf SECTIONI Historical Perspectives Anti-Inflammatory Drugs in the 21st Century Rainsford Copy of 978-1-4020-5688-8_2_Part_OnlinePDF.pdf SECTIONII Inflammatory Mechanisms of Pathogenesis 978-1-4020-5688-8_2_OnlinePDF.pdf SECTIONII Inflammatory Mechanisms of Pathogenesis Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus Weinberg et al. 978-1-4020-5688-8_3_OnlinePDF.pdf Obesity, Inflammation, and Vascular Disease Calabro and Yeh 978-1-4020-5688-8_4_OnlinePDF.pdf Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer Harris 978-1-4020-5688-8_5_OnlinePDF.pdf Role of COX-2 in Inflammatory and Degenerative Brain Diseases Luisa Minghetti Copy of 978-1-4020-5688-8_3_Part_OnlinePDF.pdf SECTIONIII Inflammation and CardiovascularDisease: The coxib controversy 978-1-4020-5688-8_6_OnlinePDF.pdf SECTIONIII Inflammation and CardiovascularDisease: The coxib controversy Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors White 978-1-4020-5688-8_7_OnlinePDF.pdf COX-2 Inhibitors And CardiovascularRisk Salzberg and Weir 978-1-4020-5688-8_8_OnlinePDF.pdf A Biological Rationale for the Cardiotoxic Effects of Rofecoxib Mason et al. Copy of 978-1-4020-5688-8_4_Part_OnlinePDF.pdf SECTIONIV COX-2 Blockade in Cancer Prevention and Therapy 978-1-4020-5688-8_9_OnlinePDF.pdf SECTIONIV COX-2 Blockade in Cancer Prevention and Therapy Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade Harris et al. 978-1-4020-5688-8_10_OnlinePDF.pdf Strategies for Colon Cancer Prevention Reddy Copy of 978-1-4020-5688-8_5_Part_OnlinePDF.pdf SECTIONV Inflammation and Neurodegenerative Disease 978-1-4020-5688-8_11_OnlinePDF.pdf SECTIONV Inflammation and Neurodegenerative Disease NSAID1s for the Chemoprevention of Alzheimer's Disease Szekely et al. 978-1-4020-5688-8_12_OnlinePDF.pdf Inflammation in parkinson's disease Hald et al. Copy of 978-1-4020-5688-8_6_Part_OnlinePDF.pdf SECTIONVI Nutrition, inflammation and Chronic Disease 978-1-4020-5688-8_13_OnlinePDF.pdf SECTIONVI Nutrition, inflammation and Chronic Disease Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases Lorgeril 978-1-4020-5688-8_14_OnlinePDF.pdf Nutritional Intervention in Brain Aging Lau et al. 978-1-4020-5688-8_BookBackMatter_OnlinePDF.pdf