Inflammation in Parkinson's Disease [recurso electrónico] Scientific and Clinical Aspects

Parkinson’s Disease (PD) is a progressive neurodegenerative disease with a prevalence of 0.1% of the global population, and 5-10% patients are under 40 years of age. Several text books have been published on various aspects of PD to date, including research and clinical aspects. However these do not emphasize the inflammatory pathways and pathways of neurodegeneration in PD. __Inflammation in Parkinson’s Disease__ brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation. Front Matter....Pages i-xvi Parkinson’s Disease: An Overview of Etiology, Clinical Manifestations, and Treatment....Pages 1-24 Neuropathology of Parkinson’s Disease....Pages 25-74 Role of the Innate and Adaptive Immune System in the Pathogenesis of PD....Pages 75-103 “Good” and “Bad” Microglia in Parkinson’s Disease: An Understanding of Homeostatic Mechanisms in Immunomodulation....Pages 105-126 The Role of Astrocytes in Parkinson’s Disease....Pages 127-144 Proinflammatory Chemical Signaling: Cytokines....Pages 145-173 Cell Culture Models of Inflammation in Parkinson’s Disease....Pages 175-187 Clinical Aspects of Inflammation in Parkinson’s Disease....Pages 189-204 PET Imaging in Neuroinflammation....Pages 205-216 Back Matter....Pages 217-222 Madhavi Thomas, Editor. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.