Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts: Proceedings of the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins Lancaster, U. K. , 20-25 July 1986

The contents of this volume originate from the joint Inclusion Phenomenal Cyclodextrins Symposium held at Lancaster in July 1986. Consisting of 50 extended ab­ stracts and 21 original contributions, the reader will find an up-to-date survey of the current state of research into, and applications of, inclusion compounds. Topics covered range from cyclodextrin complexes and their use as media for selective chemical reagents and their applications in chromatography and in the pharmaceutical and agricultural areas; the synthesis of new hosts, particularly those containing hydrophobic cavities; the characterisation of inclusion compounds using crystallographic and spectroscopic techniques; the use of inclusion com­ pounds as enzyme models; macrocyclic complexes and ionophores; to intercalates and zeolites. The Symposium was extremely successful, being attended by some 250 delegates drawn from 23 nations. It is hoped that the reader will recapture the flavour of the meeting from reading this volume. xi Journal of Inclusion Phenomena 5 (1987), 1-2. 1 © 1987 by D. Reidel Publishing Company. Preface The joint meeting comprlslng the 4th International Symposium on Inclusion Phenomena and the 3rd International Symposium on Cyclodextrins was held on 20 - 25 July, 1986 at the University of Lancaster, Great Britain, and followed on from the previous joint meeting held in Tokyo in July, 1984. The meeting was sponsored by the Royal Society of Chemistry. Front Matter....Pages i-xi Developments in Cyclodextrin Applications in Drug Formulations....Pages 29-38 Increasing the Solubility of Drugs Through Cyclodextrin Complexation....Pages 39-43 Ability of the Acetotoluides to Form Cyclodextrin Inclusion Complexes....Pages 45-47 The Inclusion of the Drug Diflunisal by Alpha- and Beta- Cyclodextrins. A Nuclear Magnetic Resonance and Ultraviolet Spectroscopic Study....Pages 49-53 Geometry of α-Cyclodextrin Inclusion Complex with m-Nitrophenol Deduced from Quantum Chemical Analysis of Carbon-13 Chemical Shifts....Pages 55-58 The Inclusion of Pyronine B and Pyronine Y by Beta- and Gamma- Cyclodextrins. A Kinetic and Equilibrium Study.....Pages 59-63 2 H NMR Studies of Metallocenes in Host Lattices....Pages 65-68 Separation Processes in Gas-Liquid Chromatography Based on Formation of α-Cyclodextrin - Chiral Hydrocarbons Inclusion Complexes....Pages 69-72 Novel HPLC Adsorbents by Immobilization of Modified Cyclodextrins....Pages 73-76 Conformational and Enantiomeric Discrimination in Cyclodextrin Inclusion Compounds....Pages 77-84 Reaction of Cyclodextrin-Nicotinamide as a Nadh Coenzyme Model....Pages 85-91 Catalytic Activity of ß-Cyclodextrin-Histamine....Pages 93-98 Modifications of Benzoxazole Ring Substituents in A.23187 (Calcimycin).Effect on Cation Carrier Properties....Pages 99-102 Ion Transport, Ion Extraction, and Ion Binding by Synthetic Cyclic Octapeptide....Pages 103-108 Synthetic Analogs of Peptide-Binding Antibiotics....Pages 109-111 Molecular Graphics in the Study of the Calcium-Binding Sites of Carp Parvalbumin and Other Proteins....Pages 113-116 Synthesis and Conformational Studies of a New Host System Based on Cholic Acid....Pages 117-121 Solid State Studies on p.t-Butyl-Calix[6]Arene Derivatives....Pages 123-126 Topology of N-Ethylmaleimide in Normal Human Erythrocyte Membrane....Pages 127-134 An Equilibrium and Kinetic Study of the Complexation of Lithium and Sodium Ions by the Cryptand 4, 7,13-Trioxa-l, 10-Diazabicyclo- [8.5.5] - Eicosane (C21C 5 ).....Pages 137-141 Metal-Free Macrocycles Via Template Method: A Starting Point for Selective Complexation Studies....Pages 143-148 Torands: Planar Polyazamacrocyclic Ligands for Metal Ions....Pages 149-152 Synthesis of Symmetrical N-Tosyldiazamacrocycles and Complexation Properties of their Derivatives....Pages 153-156 Size and Charge Dependence of Binding by Azacyclophanes....Pages 157-160 Multiple Recognition in Polytopic Anion Hosts....Pages 161-164 Crystal Structures of 1:1 Complexes Between Urea and Two Crown Ether Derivatives of Phthalic Acid....Pages 165-168 Transition Metal Complexes of Homoleptic Polythia Crowns....Pages 169-172 Isolation, Properties and Association Phenomena of Alkaline Salts and Their Crown Complexes of a Radical Anion....Pages 173-176 Synthesis and Complexing Properties of a Chiral Macrocyclic Molecular Receptor with Convergent Binding Sites....Pages 177-180 Organometallic Ionophore for Alkali Metal Cations....Pages 181-185 Solid Clathrate Solutions....Pages 187-194 Clathrate Thermodynamics for the Unstable Host Framework....Pages 195-202 Clathrate Formation in Water-Tetraalkyl Ammonium Iodide Systems at High Pressure....Pages 203-210 Catenated and Non-Catenated Inclusion Complexes of Trimesic Acid....Pages 211-214 Selectivity of the Host Ni(4-mepy) 4 ,(NCS) 2 Towards Aromatic Guests....Pages 215-217 Some Physical and Thermophysical Properties of Clathrate Hydrates....Pages 219-223 Three-Dimensional Metal Complex Hosts Built of α, ω-(Long-Carbon-Chain)-Diaminoalkane Ligand Bridging Two-Dimensional Cyanometal Complex Network: Hofmann-Diaminoalkane-Type Clathrates....Pages 225-228 Molecular Determinants of a New Family of Helical Tubuland Host Diols....Pages 229-232 Synthesis and Structure of Hexakis( p -Hydroxyphenyloxy)Benzene: A Versatile Analogue of the Hydrogen-Bonded Hexameric Unit of β-Hydroquinone....Pages 233-239 Free Radicals as Host Molecules....Pages 241-244 35 Cl Nuclear Quadrupole Resonance studies of CCl 4 as a guest molecule in various clathrates....Pages 245-248 Inclusion Polymerization of Diene and Diacetylene Monomers in Deoxycholic Acid and Apocholic Acid Canals....Pages 249-252 Correlation Between Layer Charge and Activation Energy of Thermally Induced Deintercalation in Organo-Layer Silicates....Pages 253-257 Infrared Spectral Investigations of Adsorption and Oxidation of N,N-Dimethylaniline by Sepiolite, Loughlinite and Diatomite....Pages 259-262 Lithium Intercalation Cluster Compounds....Pages 263-264 Metal-Containing Cellulose: Some Novel Materials....Pages 265-268 Generation and Management of Three-Dimensional Structural Diagrams for Zeolites on Standard Graphical Support of an IBM-PC....Pages 269-271 ESR and X-ray Diffraction Studies of Diacyl Peroxides in Urea and Aluminosilicate Hosts....Pages 273-277 Aluminate Sodalites — A Family of Inclusion Compounds with Strong Host-Guest Interactions....Pages 279-282 Synthesis, Crystallographic, and Thermal Properties of a NEW Porous Silica....Pages 283-287 The Effect of Water Vapour on the Cyclodextrin-Solute Interaction in Gas-Solid Chromatography....Pages 289-297 The Inclusion Complex of Piromidic Acid with Dimethyl-ß-cyclodextrin in Aqueous Solution and in the Solid State....Pages 299-305 Improvement of Fat Digestion in Rats by Dimethyl- ß -cyclodextrin....Pages 307-311 Reduction of Phytotoxicity of Nonionic Tensides by Cyclodextrins....Pages 313-317 Water Soluble Cyclodextrin Polymers: Their Interaction with Drugs....Pages 319-323 Cyclodextrins Lessen the Membrane Damaging Effect of Nonionic Tensides....Pages 325-329 Effect of Cyclodextrin Complexation on the Reduction of Menthone and Isomenthone....Pages 331-334 ß -Cyclodextrin-Catalyzed Effects on the Hydrolysis of Esters of Aromatic Acids....Pages 335-339 Asymmetric Halogenation and Hydrohalogenation of Styrene in Crystalline Cyclodextrin Complexes....Pages 341-350 13 C Nuclear Magnetic Resonance Spectra of Cyclodextrin Monomers, Derivatives and their Complexes with Methyl Orange....Pages 351-360 Complexes of Na-, Ca-, and Zn-Montmorillonites with an Aminated Cyclodextrin....Pages 361-364 Synthesis of an Intercalated Compound of Montmorillonite and 6-Polyamide....Pages 365-374 Isomorphous Substitution Effects on the Thermally Induced Interlayer Reaction in N -Hexylammonium Layered Aluminosilicates....Pages 375-382 Vibrational Spectroscopic Studies of 4,4′-Bipyridyl Metal(II) Tetracyanonickelate Complexes and their Clathrates....Pages 383-389 The Synthesis of Metallocene Calix[4]arenes....Pages 391-396 Solid State and Solution Structures of the Lanthanide Complexes with Cryptand (2.2.1): Crystallographic and NMR Studies of a Dimeric Praseodymium (2.2.1) Cryptate Containing Two μ-Hydroxo Bridges....Pages 397-405 Synthesis and Alkali Metal Cation Complexation of N -Aryl [3.2.2] Cryptands....Pages 407-411 Redox Responsive Metal Complexes Containing Cation Binding Sites....Pages 413-416 Binding Properties of Alginic Acid and Chitin....Pages 417-426 The Molecular Anvil Model of an Enzyme Taking into Consideration the Flexibility of Enzyme Molecules....Pages 427-436 Display of Cross-Sections Showing Packing in Inclusion Compounds....Pages 437-441 Erratum to: The Inclusion of Pyronine B and Pyronine Y by Beta- and Gamma- Cyclodextrins. A Kinetic and Equilibrium Study.....Pages 443-443 Back Matter....Pages 445-455 Proceedings of the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, UK, July 20-25, 1986