In Vivo Imaging Of Cancer Therapy (cancer Drug Discovery And Development)

Imaging studies are frequently used to evaluate the success of cancer treatments for a variety of tumor types. In Vivo Imaging of Cancer Therapy addresses a variety of cutting-edge imaging techniques, including their use for best practice, and provides examples of results found in both pre-clinical and clinical studies. This comprehensive text covers the entire spectrum of in vivo imaging for oncology, including current approaches to detailed anatomic measurements, MR and optical spectroscopy, and molecular imaging techniques requiring exogenously administered imaging agents. The challenges and approaches to quantification are also outlined. The authors describe technologies and methods that are currently clinically available, and many that are still in a developmental stage or useful only in animal studies. However, it is important to realize that the majority of imaging devices now offered for sale by the major imaging equipment manufacturers did not exist as recently as 3 or 4 years ago. Thus the pace of technology development is such that techniques described here as laboratory or investigational will likely be in clinical use within a few years. In vivo imaging will continue to have profound effects on how we think about, detect, diagnose, treat and monitor cancer. In Vivo Imaging of Cancer Therapy will aide clinicians at all levels in keeping up with the most cutting-edge techniques. Front Matter....Pages i-xii Role of Imaging in Cancer Treatment....Pages 1-12 Preclinical Models of Tumor Growth and Response....Pages 13-32 Anatomical Measure of Tumor Growth with Computed Tomography and Magnetic Resonance Imaging....Pages 33-46 Positron Emission Tomography Imaging of Blood Flow and Hypoxia in Tumors....Pages 47-71 Magnetic Resonance Measurement of Tumor Perfusion and Vascularity....Pages 73-84 Computed Tomography Measurements of Perfusion in Cancer Therapy....Pages 85-102 [ 18 F]Fluorodeoxyglucose Positron Emission Tomography Assessment of Response....Pages 103-120 Measurement of Tumor Proliferation with Positron Emission Tomography and Treatment Response....Pages 121-142 Estrogen-Receptor Imaging and Assessing Response to Hormonal Therapy of Breast Cancer....Pages 143-153 Quantitative Approaches to Positron Emission Tomography....Pages 155-167 Positron Emission Tomography Measurement of Drug Kinetics....Pages 169-204 Imaging Genes for Viral and Adoptive Therapies....Pages 205-239 In Vivo Magnetic Resonance Spectroscopy in Clinical Oncology....Pages 241-258 Magnetic Resonance Probes for Tumor Imaging....Pages 259-280 Fluorescent Imaging of Tumors....Pages 281-302 Imaging of Apoptosis....Pages 303-316 Back Matter....Pages 317-326 Imaging studies are frequently used to evaluate the success of cancer treatments for a variety of tumor types. This text addresses a variety of cutting-edge imaging techniques, including their use for best practice, and provides examples of results found in both pre-clinical and clinical studies. It covers the entire spectrum of in vivo imaging for oncology, including current approaches to detailed anatomic measurements, MR and optical spectroscopy, and molecular imaging techniques requiring exogenously administered imaging agents. The challenges and approaches to quantification are also outlined. In vivo imaging will continue to have profound effects on how we think about, detect, diagnose, treat and monitor cancer. It will aide clinicians at all levels in keeping up with the most cutting-edge techniques A Variety Of Cutting-edge Imaging Techniques, Including Their Use For Best Practice, Are Addressed In This Book. The Book Also Provides Examples Of Results Found In Both Pre-clinical And Clinical Studies. This Comprehensive Text Covers The Entire Spectrum Of In Vivo Imaging For Oncology. It Will Aide Clinicians At All Levels In Keeping Up With The Most Cutting-edge Techniques.