In Vivo EPR (ESR): Theory and Application (Biological Magnetic Resonance, 18)

**In Vivo EPR (ESR)** is a textbook on this relatively new subject in biomedical electron spin resonance. While a few chapters have appeared in special topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrumentation, and aspects of biochemistry, in vitro and in vivo applications. A significant amount of detail is devoted to clinical applications and the problems and pitfalls encountered in in vivo spectroscopy and imaging. Key Features: -History of In Vivo EPR, -Principles of Imaging-Theory and Instrumentation, -Time-domain Radio Frequency EPR Imaging, -The Measurement of Oxygen In Vivo Using In Vivo EPR Techniques, -Potential Medical (Clinical) Applications of EPR, -Combining NMR and EPR/ESR for In Vivo Experiments. Front Matter....Pages i-xxvii Introduction to in Vivo EPR....Pages 1-20 Principles of in Vivo EPR....Pages 23-40 Frequency and Power Considerations for In-Vivo EPR and Related Techniques....Pages 41-59 CW EPR Signal Detection Bridges....Pages 61-72 Resonators for Low-Field In Vivo EPR....Pages 73-97 Principles of Imaging....Pages 99-152 Time-Domain Radio Frequency EPR Imaging....Pages 153-197 Stable Soluble Paramagnetic Compounds....Pages 201-232 Stable Particulate Paramagnetic Materials as Oxygen Sensors in EPR Oximetry....Pages 233-257 Packaging of Paramagnetic Materials in Oximetry and Other Applications....Pages 259-284 Spin Trapping in Vivo: Facts and Artifacts....Pages 285-308 Ex Vivo Detection of Free Radical Metabolites of Toxic Chemicals and Drugs by Spin Trapping....Pages 309-323 Chemistry and Biology of Nitric Oxide....Pages 325-379 In Vivo and in Vitro Detection of NO by EPR....Pages 381-402 The Measurement of Oxygen in Vivo Using EPR Techniques....Pages 403-440 Cardiac Applications of in Vivo EPR Spectroscopy and Imaging....Pages 441-468 Applications of in Vivo EPR Spectroscopy and Imaging in Cancer Research....Pages 469-482 Applications of in Vivo EPR Spectroscopy and Imaging to Skin....Pages 483-513 Pharmaceutical Applications of In Vivo EPR....Pages 515-545 Proton-Electron Double-Resonance Imaging (PEDRI)....Pages 547-578 Combining NMR and EPR/ESR for in Vivo Experiments....Pages 579-597 Potential Medical (Clinical) Applications of EPR: Overview & Perspectives....Pages 599-621 Back Matter....Pages 623-656

this Handbook For Students And Researchers Describes The Theory And Applications Of in Vivo Electron Paramagnetic Resonance Spectroscopy (epr). Each Of 22 Contributions From Experts In The Field Introduces A Subtopic, Describes Research Results Already Achieved In That Area, And Assesses The Possibilities For Further Research. The Authors Also Present Information On Cautions And Laboratory Techniques Not Normally Included In These Types Of Papers. Particular Attention Has Been Paid To The Clinical Applications Of Epr. Editor Berliner Teaches Chemistry And Biochemistry At The U. Of Denver. Annotation ©2004 Book News, Inc., Portland, Or

In vivo EPR already has made significant contributions to the understanding of basic physiology and pathophysiology.