Implications of Psychopharmacology to Psychiatry : Biological, Nosological, and Therapeutical Concepts

The discovery of chlorpromazine 40 years ago and of other compounds for the specific treatment of psychiatric disorders had marked influence on clinical psychiatry and basic neuroscience. Since then, the development of psychopharmacology and theories of psychiatric disorders have become closely interrelated. On the occasion of the 70th birthday of Hanns Hippius - one of the pioneers of clinical psychopharmacology - leading experts in this field and related disciplines met to present and discuss their views and theories on psychiatric disorders. Future perspectives of drug development, genetic research in psychiatry, nosological and diagnostic concepts, and strategies for more specific treatment of various psychiatric disorders were presented. This was a unique occasion for most of the prominent and leading experts worldwide to contribute to this book. The reader is given broad insight into the research and clinical perspectives of psychiatry. The discovery of chlorpromazine for the specific treatment of schizophrenic symp­ toms and, later on, of imipramine for the specific treatment of depressive symptoms marked a new milestone in clinical psychiatry and basic neuroscience 40 years ago. The exploration of biochemical mechanisms of action of these psychotropic drugs created new theories on the pathophysiology of psychiatric disorders, such as the dopamine hypothesis of schizophrenia and the catecholamine and serotonin hypotheses of depression. Thus the discovery of these biological treatments had a major impact on natural science-oriented research. Biological psychiatry as we know it today has its origin in these psychopharmacological drugs and influences many disciplines in psychiatry. It was a fortunate coincidence that Hans Hippius, whose 70th birthday we celebrated this year with an international symposium, started his professional career during this time in the 1950S. He was one of the early pioneers in clinical psycho­ pharmacological research and enthusiastic about both the scientific and the thera­ peutic prospects of the new psychotropic drugs. He has worked in this field for more than three decades and has made many lasting contributions to biological psychiatry. Among the many activities, his contributions in the development of the new atypical antipsychotic drug clozapine should be mentioned. Front Matter....Pages i-x Neurotransmitter Interactions Important for Schizophrenia....Pages 1-12 The Etiology of Affective Illness....Pages 13-22 New Findings in the Genetics of Bipolar Illness....Pages 23-33 Targeting the Action of Antidepressant Drugs on Second-Messenger Systems....Pages 34-40 New Concepts of Schizophrenia Derived from Epidemiological Research....Pages 41-55 The Course of Psychiatric Disorders as a Diagnostic Tool....Pages 56-65 A Psychoanalytic Model for the Classification of Personality Disorders....Pages 66-78 Functional Psychopathology: An Essential Diagnostic Step in Biological Psychiatric Research....Pages 79-88 The Development of Nosological Concepts in Anxiety Disorders....Pages 89-100 Classification of the Affective and Related Disorders....Pages 101-126 The Ideal Neuroleptic....Pages 127-137 Long-Term Treatment of Schizophrenia....Pages 138-149 Treatment of Affective Disorders....Pages 150-157 Negative Symptoms of Schizophrenia: Methodological Issues, Biochemical Findings and Efficacy of Neuroleptic Treatment....Pages 158-178 Interaction of Long-Term Antidepressant Treatment with Psychosocial Factors....Pages 179-187 Back Matter....Pages 189-189 The discovery of chlorpromazine 40 years ago and of other compounds for the treatment of psychiatric disorders had marked influence on clinical psychiatry and basic neuro-science. Since then, the development of psychopharmacology and theories of psychiatric disorders have become closely interrelated. On the occasion of the 70th birthday of Hanns Hippius - a pioneer of clinical psychopharmacology - leading experts in this field and related disciplines met to present their views and theories on psychiatric disorders. Future perspectives of drug development, genetic research, nosological and diagnostic concepts, and strategies for more specific treatment of various psychiatric disorders were presented. The reader is given broad insight into the research and clinical perspectives of psychiatry.

The book contains black-and-white illustrations.