Impact of Genetic Targets on Cancer Therapy (Advances in Experimental Medicine and Biology)

The volume provides a forum for original peer-reviewed short communications, full-length research and review articles on new research findings and developments on the topic of genetic targets on cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to move the field forward. Each chapter includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells. Front Matter....Pages i-viii Novel Antineoplastics Targeting Genetic Changes in Colorectal Cancer....Pages 1-34 Update on Clinical Trials: Genetic Targets in Breast Cancer....Pages 35-54 Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer....Pages 55-65 Impact of Genetic Targets on Cancer Therapy: Hepatocellular Cancer....Pages 67-90 Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular Phenotype....Pages 91-143 Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer....Pages 145-164 Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma....Pages 165-177 Tyrosine Kinase Targeted Treatment of Chronic Myelogenous Leukemia and Other Myeloproliferative Neoplasms....Pages 179-196 Targeted Therapy of Multiple Myeloma....Pages 197-221 Current and Future Trials of Targeted Therapies in Cutaneous Melanoma....Pages 223-255 Current Approaches to Epigenetic Therapy for the Treatment of Mantle Cell Lymphoma....Pages 257-266 Impact of Genetic Targets on Primary Brain Tumor Therapy: What’s Ready for Prime Time?....Pages 267-289 Rational Therapy for Renal Cell Carcinoma Based on its Genetic Targets....Pages 291-308 Molecular and Genetic Markers of Follicular-Cell Thyroid Cancer: Etiology and Diagnostic and Therapeutic Opportunities....Pages 309-326 Genetic Targets in Pediatric Acute Lymphoblastic Leukemia....Pages 327-340 Emerging Molecular Therapies for the Treatment of Acute Lymphoblastic Leukemia....Pages 341-358 Impact of Genetic Targets on Prostate Cancer Therapy....Pages 359-383 Small-Cell Lung Cancer: An Update on Targeted Therapies....Pages 385-404 Impact of Genetic Targets on Cancer Therapy in Acute Myelogenous Leukemia....Pages 405-437 Back Matter....Pages 439-446 The topic of 'Impact of genetic targets on cancer therapy' has reviews that each focuses on a specific tumor type, review recent knowledge about molecular pathogenesis in general and especially as it impacts response to therapy. The topic is aimed to provide a forum for publication of original peer-reviewed short communications, full-length research and review articles on new research findings and developments in cancer therapies