Immunotoxicology and Immunopharmacology, Third Edition (Target Organ Toxicology Series)

Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals. Front cover 1 Title Page 2 ISBN 0849337909 5 DEDICATION 6 Contents 8 Preface to the Third Edition 14 Preface to the Second Edition 15 Preface to the First Edition 16 Acknowledgments 18 Contributors 20 Part I: Immunotoxicology and Hazard Identification 26 Chapter 1. Immunotoxicology: Thirty Years and Counting 28 Chapter 2. Immunotoxicity Hazard Identification and Testing Guidelines 46 Chapter 3. Interpreting Immunotoxicology Data for Risk Assessment 60 Chapter 4. Mechanisms of Immunotoxicity 74 Chapter 5. Animal and In Vitro Models of Immunotoxicity 88 Chapter 6. The Promise of Genomics and Proteomics in Immunotoxicology and Immunopharmacology 104 Chapter 7. The Use of Multiparameter Flow Cytometry in Immunotoxicology and Immunopharmacology 122 Part II: Immunopharmacology and Immunotoxicology of Therapeutics 148 Chapter 8. Targeted Therapeutic Immune Response Modulators 150 Chapter 9. Immunoaugmenting Therapeutics: Recombinant Cytokines and Biological Response Modifiers 168 Chapter 10. Opioid-Induced Immunomodulation 196 Chapter 11. Immunomodulation by Nutraceuticals and Functional Foods 210 Part III: Environmental Agents 230 Chapter 12. Lead Immunotoxicity 232 Chapter 13. Immunotoxicology of Jet Propulsion Fuel-8 250 Chapter 14. Immune Modulation by TCDD and Related Polyhalogenated Aromatic Hydrocarbons 264 Chapter 15. Mechanisms by Which Ultraviolet Radiation, a Ubiquitous Environmental Toxin, Suppresses the Immune Response 284 Chapter 16. Immunotoxicology and Inflammatory Mechanisms of Arsenic 302 Chapter 17. Modulation of Inflammatory Gene Expression by Trichothecene Mycotoxins 316 Part IV: Immunotoxicity in the Lung 330 Chapter 18. Host Defense and Immunotoxicology of the Lung 332 Part V: Developing Immunotoxicity 350 Chapter 19. Immune System Ontogeny and Developmental Immunotoxicology 352 Chapter 20. Development of a Framework for Developmental Immunotoxicity (DIT) Testing 372 Part VI: Wildlife Immunotoxicology 388 Chapter 21. Invertebrate Immunotoxicology 390 Chapter 22. Amphibian, Fish, and Bird Immunotoxicology 410 Chapter 23. Marine Mammal Immunotoxicology 428 Part VII: Autoimmunity and Autoimmune Diseases 446 Chapter 24. Immunopathogenesis of Autoimmune Diseases 448 Chapter 25. Environmental Influences on Autoimmunity and Autoimmune Diseases 462 Chapter 26. Drug-Induced Autoimmune Disease 480 Chapter 27. Experimental Models of Autoimmunity 494 Part VIII: Neuroimmunology 512 Chapter 28. An Overview of Neural-Immune Communication in Development, Adulthood, and Aging 514 Chapter 29. Stress, Immune Function, and Resistance to Disease: Human and Rodent Models 534 Chapter 30. Recreational Drugs, Immune Function, and Resistance to Infection 552 Part IX: Allergy and Hypersensitivity 566 Chapter 31. Allergy to Chemicals and Proteins: An Introduction 568 Chapter 32. Allergic Contact Dermatitis to Chemicals: Immunological and Clinical Aspects 584 Chapter 33. Respiratory Allergy and Occupational Asthma 600 Chapter 34. Chemical Allergy: Hazard Identification, Hazard Characterization, and Risk Assessment 616 Chapter 35. Food Allergy: Immunological Aspects and Approaches to Safety Assessment 632 Chapter 36. Drug Allergy 648 Index 658 Back cover 676