Immunotherapy of Cancer (Cancer Drug Discovery and Development)

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined. Discovery Of Target Molecules For Cancer Immunotherapy By Genetic And Bioinformatic Approaches -- Current Strategies For The Identification Of Immunogenic Epitopes Of Tumor Antigens -- Current And Future Role Of Natural-killer Cells In Cancer Immunotherapy -- The Role Of Immune Monitoring In Evaluating Cancer Immunotherapy -- Statistical Analysis Of Immune Response Assays -- Dna Vaccines For Cancer Immunotherapy -- Dendritic Cells -- Different Approaches To Dendritic Cell-based Cancer Immunotherapy -- Anti-idiotype Antibody Vaccines For The Immunotherapy Of Cancer -- Autologous Tumor-derived Heat Shock Protein Vaccine As A New Paradigm For Individualized Cancer Therapeutics -- Tumor-reactive T-cells For Adoptive Immunotherapy -- T-cell Adoptive Immunotherapy Of Cancer: From Translational Models To Clinical Significance -- Retroviral-mediated Gene Transfer For Engineering Tumor-reactive T-cells -- Harnessing The Potential Of Graft-vs-tumor -- Tumor-induced Immune Suppression And Immune Escape: Mechanisms And Impact On The Outcome Of Immunotherapy Of Malignant Disease -- The Tumor Microenvironment: Regulation Of Antitumor Immunity And Implications For Immunotherapy -- Manipulation Of Lymphocyte Homeostasis For Enhancing Antitumor Immunity -- Fast-lane Evolution In The Tumor Microenvironment -- Manipulating Immunological Checkpoints To Maximize Antitumor Immunity -- Interleukin-2 As Cancer Therapy -- Biological And Clinical Properties Of The Type 1 Interferons -- Promising G [gamma]-chain Cytokines For Cancer Immunotherapy: Interleukins-7, -15, And -21 As Vaccine Adjuvants, Growth Factors -- The Therapeutic Use Of Natural-killer Cells In Hematological Malignancies -- Antibody Therapy For Solid Tumors -- Antibody Therapy For Non-hodgkin's Lymphoma -- Approaches To In Vivo Imaging Of Cancer Immunotherapy -- Design Issues For Early-stage Clinical Trials For Cancer Vaccines -- Monoclonal Antibody Therapy For Cancer. Edited By Mary L. Disis. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Cover.jpg......Page 1 front-matter.pdf......Page 2 1.pdf......Page 14 21.pdf......Page 33 45.pdf......Page 57 59.pdf......Page 71 73.pdf......Page 85 87.pdf......Page 98 115.pdf......Page 126 127.pdf......Page 138 139.pdf......Page 150 151.pdf......Page 161 167.pdf......Page 177 181.pdf......Page 190 213.pdf......Page 222 235.pdf......Page 243 263.pdf......Page 270 285.pdf......Page 292 303.pdf......Page 309 317.pdf......Page 323 331.pdf......Page 336 355.pdf......Page 359 365.pdf......Page 369 397.pdf......Page 401 415.pdf......Page 419 433.pdf......Page 437 445.pdf......Page 449 457.pdf......Page 460 479.pdf......Page 481 487.pdf......Page 488 back-matter.pdf......Page 504 Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis - both of clinical trials and assay evaluations - methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challe