Immunosuppression Under Trial : Proceedings of the 31st Conference on Transplantation and Clinical Immunology, 3–4 June, 1999

Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies. Front Matter....Pages i-ix Front Matter....Pages 1-1 Current results as reference for future improvements in immunosuppression....Pages 3-9 Rationale of clinical trials from the physician....Pages 11-13 Minimal standards for reporting clinical trial results in transplantation....Pages 15-24 Methodological approach of clinical trials for renal transplantation....Pages 25-37 Front Matter....Pages 39-39 Surrogate end-points for clinical trials in renal transplantation....Pages 41-51 Is acute rejection an appropriate surrogate marker for clinical trials in liver transplantation?....Pages 53-56 The success of clinical immunosuppressive trials in heart transplantation: the early detection of acute rejection....Pages 57-59 Front Matter....Pages 61-61 Factors influencing long-term allograft survival....Pages 63-65 Front Matter....Pages 67-67 Patients’ appraisal of side effects in quality of life assessments of immunosuppressive regimens....Pages 69-80 Cardiovascular complications after renal transplantation....Pages 81-88 Strategies to minimize nephrotoxicity associated to calcineurin inhibitors....Pages 89-99 Diabetogenic effect of immunosuppressive drugs....Pages 101-103 Can we minimize long-term side effects of immunosuppressive drugs on lipid metabolism?....Pages 105-109 Can we minimize the long-term side effects of immunosuppressive drugs in pediatric patients?....Pages 111-121 Front Matter....Pages 123-123 Induction therapy....Pages 125-129 Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens....Pages 131-144 Immunosuppression in composite tissue transplantation....Pages 145-151 The search for immunosuppressive synergy....Pages 153-155 Economic analysis of immunosuppression in transplantation: a review of recent studies in liver and kidney transplantation....Pages 157-166 Front Matter....Pages 167-167 Questions raised by the exclusion of ‘at risk’ conditions from current trials in organ transplantation....Pages 169-178 Back Matter....Pages 179-179