Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies (Molecular and Integrative Toxicology)

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume__, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems__, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of __Immunopathology in Toxicology and Drug Development__ are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. Front Matter....Pages i-xxii Basic Immunobiology....Pages 1-93 Cells of the Immune System....Pages 95-201 Signaling and Effector Molecules in Immunity....Pages 203-243 Development of Immune System Organs....Pages 245-294 Aging of Immune System Organs....Pages 295-342 Flow Cytometry and Immunophenotyping in Drug Development....Pages 343-369 Pathology Evaluation for Detection of Immunomodulation....Pages 371-442 Enhanced Immunohistopathology....Pages 443-456 Clinical Pathology Assays in Immunopathology....Pages 457-488 Application of Immunohistochemistry in Toxicologic Pathology of the Hematolymphoid System....Pages 489-561 Morphometry and Stereology in Immunopathology....Pages 563-583 Molecular Techniques in Immunopathology....Pages 585-600 Current Issues in Developmental Immunotoxicity....Pages 601-618 The Murine Local Lymph Node Assay....Pages 619-637 Host Resistance Assays for Efficacy and Immunotoxicology Safety Evaluations....Pages 639-650 Back Matter....Pages 651-670