Immunology of Gastrointestinal Disease (Immunology and Medicine Book 19)

Gastrointestinal diseases present a considerable problem in human medicine in terms of both morbidity and mortality. The aim of this book is to cover the different immunological disorders of the gut with special reference to immunopathological and protective mechanisms. It will be of general interest to clinicians, scientists and students concerned with the gastrointestinal tract. Topics covered include: the current status of research into toxin-secreting pathogens, Campylobacter, Giardia and HIV; the immunological features of idiopathic inflammatory gut diseases such as Crohn's disease and intractable diarrhoea; the genesis of the flat mucosa; the iatrogenic diseases of the gut such as graft-versus-host disease and small bowel allografts; the immune mechanisms and lesions in the gut of patients with parasitic nematode infections (very important in the tropics). Basic background on the immune apparatus in the intestine is also discussed, as are the effects of inflammation on intestinal permeability. Front Matter....Pages i-xi The cells and tissues of the gastrointestinal tract....Pages 1-17 The mucosal immune system in inflammatory bowel disease....Pages 19-39 Coeliac disease....Pages 41-60 Immunology of gastrointestinal food allergy in infancy and early childhood....Pages 61-73 Immunology of intractable diarrhoea....Pages 75-86 Immunology of intestinal transplantation in humans and animals....Pages 87-103 Intestinal graft-versus-host disease....Pages 105-136 In vitro enteropathy....Pages 137-150 Molecular basis of cell migration into normal and inflamed gut....Pages 151-171 Intestinal permeation of molecules in health and disease....Pages 173-191 Immunology of gastrointestinal lymphoma....Pages 193-207 The gut in HIV infection....Pages 209-226 Immunity to enterotoxin-producing bacteria....Pages 227-246 Host responses to Helicobacter (Campylobacter) pylori infection....Pages 247-262 The immunology of giardiasis....Pages 263-282 Intestinal nematode infections....Pages 283-300 Back Matter....Pages 301-307