Immunological Diagnosis of Leukemias and Lymphomas : International Symposium of the Institut Für Hämatologie, GSF, October 28–30, 1976 — Neuherberg/Munich

This two-and-a-half-day symposium has concentrated on main aspects of the rapidly expanding field ofleukocyte markers in hematology. While leukemias are already being 'phenotyped' routinely in clinical centers, continued research on the developmental sta­ ge of cells and cell membranes, expanding into a malignant clone, permits new snap­ shots on hemopoietic differentiation. Thus the discovery of leukemia-associated anti­ gens, which so far have not been found on subpopulations of normal cells, has greatly stimulated the discussion on 'differentiation antigens versus tumor antigens'. The proceedings reflect the considerable success which has been achieved very re­ cently in the classification of hemoblastomas. Consequently the number of leukemias which are unclassifiable by immunological methods have dwindled down to a small mi­ nority. New facts give rise to new questions. By including the main points of the discussions in the proceedings, we wanted to give the reader an opportunity to get an impression of the questions and conclusions raised and drawn by the participants on the basis of new - and frequently still unpublished - data. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleages at the Institut fUr Hamatologie. Front Matter....Pages I-X The Immunological Diagnosis of Human Leukemias and Lymphomas: an Overview....Pages 1-16 Surface Markers Define Human Lymphoid Malignancies with Differing Prognoses....Pages 17-24 Cell Markers and the Classification of Acute Leukaemia....Pages 25-31 Etiological, Clinical and Prognostic Significance of the T-B Immunological Classification of Primary Acute Lymphoid Leukemias and Non Hodgkin’s Lymphomas....Pages 33-45 Surface Receptors of Human Neoplastic Lymphoreticular Cells....Pages 47-53 Non-Hodgkin Lymphomas: Cell Populations and Functional Behavior....Pages 55-60 Membrane Phenotyping: Diagnosis, Monitoring and Classification of Acute ‘Lymphoid’ Leukaemias....Pages 61-75 Cell Differentiation Antigens versus Tumor-Related Antigens in Childhood Acute Lymphoblastic Leukemia (ALL). Clinical Significance of Leukemia Markers....Pages 77-85 Classification of Leukemic Cells with T- and O-ALL-Specific Antisera....Pages 87-96 Membrane Marker Analysis of ‘Lymphoid’ and Myeloid Blast Crisis in PH 1 Positive (Chronic Myeloid) Leukemia....Pages 97-107 Myeloid Antigens and Antigen Densities in Mice and Men....Pages 109-116 Expression of T and B Cell Markers and Leukemia-Associated Antigens on Cell Surface of Human Lymphocytic Leukemias....Pages 117-124 Expression of Fc IgG -receptor (Fc IgG -r) Sites on the Surface of Neoplastic Lymphocytes....Pages 125-130 Quantitation of T-Antigenic Sites and Ig-Determinants on Leukemic Cells by Microphotometric Immunoautoradiography. Proof of the Clonal Origin of Thymus-Derived Lymphocytic Leukemias....Pages 131-145 Immunofluorometric Analyses of Membrane Bound IgM in Individual Human Lymphoid Cells in Cases of Leukemia and Malignant Lymphoma....Pages 147-156 Hairy Cell Leukemia: Simultaneous Demonstration of Autochthonous Surface-Ig and Monocytic Functions of Hairy Cells....Pages 157-162 Chronic Lymphatic Leukemia Cells Bear IgM Receptors....Pages 163-168 Acid Phosphatase in Acute Lymphatic Leukemia (ALL)....Pages 169-170 Lysosomal Acid Hydrolases in Isolated Normal and Chronic Lymphocytic Leukemia (CLL) T- and B-Lymphocytes....Pages 171-174 Prolymphocytic Leukemia with T Cell Properties and Tartrate Resistant Acid Phosphatase....Pages 175-178 Enzymecytochemical and Immunocytological Studies as a Basis for the Revaluation of the Histology of Cutaneous B-Cell and T-Cell Lymphomas....Pages 179-187 Characterization of Neoplastic Mononuclear Cells on Tissue Sections....Pages 189-196 K Cell Activity of Normal and Chronic Lymphocytic Leukaemia Lymphocytes: Association with Lymphocytes bearing Receptors for Human C3b....Pages 197-202 Comparative Studies of the Proportions of T, B and Zero Lymphocytes and the Degrees of Elastic Transformation of Lymphocytes after Stimulation by PHA and CON A in Patients with Hodgkin’s Disease....Pages 203-207 In Vitro Functions of Lymphoid Cells in Untreated Childhood Acute Lymphoblastic Leukemia....Pages 209-213 Difference in Distribution and Dynamics of Cell-Markers on T-Lymphoblasts Compared to T-Lymphocytes....Pages 215-220 Immunological Evaluation of 15 Children with Non-Hodgkin Lymphoma....Pages 221-226 Studies on the Immune Status of Children with Acute Lymphocytic Leukemia (All)....Pages 227-233 Lymphocyte Subpopulations in Lymphatic Tissues and Blood of Patients with Malignant Lymphomas....Pages 235-239 Establishment and Characterization of Leukemic T-Cell Lines, B-Cell Lines, and Null-Cell Line: a Progress Report on Surface Antigen Study of Fresh Lymphatic Leukemias in Man....Pages 241-251 Established Cell Lines as Tools in the Study of Human Lymphoma and Myeloma Cell Characteristics....Pages 253-264 Characterization of “T” and “Non-T” Cell Lines Established From Children With Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma After Leukemic Transformation....Pages 265-269 Establishment and Characterization of a Truly Leukaemic Cell Line....Pages 271-276 Characterization of a Human Hodgkin Cell Line and a Lymphoblastic EBNA-Negative Cell Line Derived from a Non-Hodgkin Lymphoma Patient....Pages 277-281 Autoradiographic Detection of the Epstein-Barr Virus (EBV)-Associated Early Antigen (EA) in Lymphoblastoid Cell Lines....Pages 283-287 Lymphoid Cell Lines: In Vitro Cell Markers in Correlation to Tumorigenicity in Nude Mice....Pages 289-296 Glucose-6-Phosphate Dehydrogenase (G-6-PD) Markers in Burkitt Lymphoma and Other Malignancies....Pages 297-305 The Significance of Chromosomal Findings for the Differentiation between Lymphoma and Lymphoblastoid Cell Lines....Pages 307-313 Isoelectric Focusing Pattern of IgM and Surface Markers in Non-Hodgkin’s Lymphomas....Pages 315-327 Idiotypic Determinants and Antiglobulins in Multiple Myeloma....Pages 329-332 New Aspects in the Classification of Leukemic Cell Types by Ia Alloantigens and Complement Receptors....Pages 333-339 Heterologous Group Specific Antiserum against Ia k Determinants....Pages 341-345 The Autoantigen Determinants I/i, Pr 1–3 of Normal and Leukemic Leucocytes....Pages 347-352 Alterations of Blood Group Receptors of Erythrocytes in Leukemia — Immunofluorescence Studies....Pages 353-359 Two Antibodies in Anti-Human T-Cell Sera....Pages 361-365 Isolation of Antilymphocyte Antibodies, with a Solid Water-Insoluble Not Gel-Like Immunoadsorbent....Pages 367-370 Cationic Proteins of Leukocyte Lysosomes: Marker Antigens for the Immunological Diagnosis of Acute Leukemias....Pages 371-377 Summing Up: International Symposium on Recent Trends in the Immunological Diagnosis of Leukemias and Lymphomas....Pages 379-382 Back Matter....Pages 383-390