Immunogenetics: Advances and Education : the First Congress of the Slovak Foundation Proceedings of the NATO Advanced Research Workshop on The First Congress of the Slovak Foundation Education in Immunogenetics Častá-Papiernička, Bratislava, Slovak Rep

M. BENcovA Slovak Foundation Education in Immunogenetics Kopanice 25, 821 04 Bratislava Slovak Republic Short History of Slovakia After the end of the 5th century, the major part of Central Europe was dominated by Slavs (Slovaks). They had already in the 7th century settle­ ments in the vicinity of towns Bratislava, Devin, Nitra to create the Slovak's state formation with the name "The Empire of Sam", territory of which corresponded to that of Slovakia of present. The Empire of Sam was also the first state formation in the Central Europe (as present states Czech Republic, Poland, Hungary, Slovakia etc. ) Very important town of this state was Nitra, with the biggest Castle in the Central Europe with his Duke Pribina. The first Church of the Central Europe was built here in the year 830, and it is now considered to be the "Slovak Bethlehem". In the year 880, Nitra also became the first Office of Bishops. Later, the Slovak Duke Pribina and Moravian Duke Mojmir (Moravia corresponded to eastern part of the present Czech Republic) joined their formations to common state "Greate Moravian Empire". The strongest King of the Great Moravian Empire was Svatopluk (864 A. D. ), who spread his empire over Czech Republic, Hungary and part of Poland, Ukraine and eastern Germany of present, which at that time still did not exist as state formations. Front Matter....Pages i-xxvi Front Matter....Pages 1-1 The Slovak Foundation: Education in Immunogenetics....Pages 3-11 Accreditation in Europe....Pages 13-19 Accreditation — A Personal View....Pages 21-23 Front Matter....Pages 25-25 HLA Diversity of Alleles and Haplotypes. The Contribution of the 12th International Histocompatibility Workshop....Pages 27-31 The Associated Polymorphisms of HLA-DR2: Genotyping of DRB1, DRB5, DQB1 Loci in Slovakia Caucasian Population....Pages 33-35 Paternity Testing....Pages 37-57 Front Matter....Pages 59-59 The Molecular Basis of the HLA Association in Celiac Disease....Pages 61-69 Immunogenetics of Graves’ Disease....Pages 71-86 Assessing Prognosis in Rheumatoid Arthritis Using Monoclonal Antibodies and Flow Cytometry....Pages 87-98 Hashimoto’s Thyroiditis and HLA-DR-DQ Haplotypes Associated with Control of Disease Resistance....Pages 99-101 Detection of the Tick Borne Encephalitis Virus in the Ticks and the Study of HLA Associations with the Tick Borne Encephalitis Onset....Pages 103-104 Immunogenetic Prognosis for Susceptibility to the Stomach Cancer Onset....Pages 105-106 Front Matter....Pages 107-107 Permissible Mismatches, Acceptable Mismatches and Tolerance: New Trends in Decision Making....Pages 109-120 The Application of Cellular Tests in the Selection of Unrelated Donors for Bone Marrow Transplantation....Pages 121-134 HLA Typing at the Molecular Level in the Process of Donor Selection for Bone Marrow Transplantation....Pages 135-140 Bone Marrow Transplantation at Princess Margaret Hospital, University of Toronto....Pages 141-147 Transatlantic Bone Marrow Transplantation....Pages 149-149 Front Matter....Pages 151-151 The Role of HLA-DR, DQ, DP Subregions Compatibility in the Induction of Cytotoxic T Lymphocytes in Kidney Transplantation from Living Donor....Pages 153-158 Microsatellite Testing of the Major Histocompatibility Complex in Human....Pages 159-162 NCOI Polymorphism within the TNF α Promotor Region and the First Intron of TNF β Gene in Association with DRB1 Specificities in Healthy Volunteers....Pages 163-168 Front Matter....Pages 169-169 HLA in Kidney Transplantation....Pages 171-174 Facts and Figures of Eurotransplant....Pages 175-192 Affect of Class I and Class II HLA Groups on Graft and Patient Survivals in Kidney Transplant Patients....Pages 193-199 The First Kidney Transplantation in Slovakia....Pages 201-201 HLA Class I and Class II Matched Donor Material for Improved Corneal Allograft Survival....Pages 203-214 Front Matter....Pages 215-215 HLA Typing From Serology to Molecular Biology....Pages 217-222 HLA-DP Epitope Typing Using Monoclonal Antibodies....Pages 223-232 Evolution of Molecular HLA Typing....Pages 233-242 Internet Application in the Histocompatibility Laboratory....Pages 243-254 Back Matter....Pages 255-265 The objective underlying this book is educational, aiming to advance the development of immunogenetics/histocompatibility and to encourage the international collaboration that is so necessary for the international transplant programme and for research into the genetic predisposition to develop diseases associated with genes in the HLA complex. The revolution in high-tech molecular biological genome technology has given rise to a prodigious development of molecular techniques for the polymorphism analysis of HLA and the subsequent application of research results in clinical practice. Many new alleles have been discovered and different mechanisms have been shown to generate these new alleles. This has improved both diagnostic efficiency and increased the success of transplantation. Topics covered include HLA associated susceptibility to autoimmune disease. Strategies and efficiency of BMDW and benefit of collaboration. Optimum selection of unrelated bone marrow donor and extension of the pool of suitable donors by determination of possible mismatches. Identification of sibling pairs using microsatellites across the HLA region. HLA in kidney transplantation. Eurotransplant facts and figures. HLA typing from serology to molecular biology. Evolution of DNA based typing in HLA laboratories. HLA and paternity testing Proceedings of the NATO Advanced Research Workshop, held in Casta-Papiernicka, Bratislava, Slovak Republic, September 5-9, 1996