Immunogenetics

Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology. Content: Front Matter, Page iii Copyright, Page iv Preface, Page v, G.S.P., C.D. Contributors, Pages vi-viii 1 - Major histocompatibility complex genes and their role in autoimmune and infectious diseases, Pages 1-25, Paul H. Wooley, Chella S. David 2 - The human major histocompatibility complex (MHC), Pages 26-49, M.R. Laurent, K.I. Welsh 3 - Complement genes of the human major histocompatibility complex: implications for linkage disequilibrium and disease associations, Pages 50-91, Chester A. Alper, Zuheir L. Awdeh, Donald D. Raum, Ellen Fleischnick, Edmond J. Yunis 4 - Genetics of human immunoglobulins, Pages 92-109, J.P. Pandey, H.D. Whitten, H.H. Fudenberg 5 - The spondoarthritides, Pages 110-139, Anja Tiilikainen 6 - Genetic studies of rheumatoid arthritis, Pages 140-156, G.S. Panayi 7 - Genetics of systemic lupus erythematosus, Pages 157-176, Mark J. Walport, Angela H.L. Fielder, J.Richard Batchelor 8 - Immunogenetics of multiple sclerosis, Pages 177-206, Joel J.F. Oger, Barry G.W. Arnason 9 - Autoimmune thyroid disease, Pages 207-233, C.L. Burek, N.R. Rose, G.M. Najar, A. Gimelfarb, C.M. Zmijewski, H.F. Polesky, W.H. Hoffman 10 - T-cell clones, Pages 234-259, Frank W. Fitch 11 - Molecular immunology: genes of the major histocompatibility complex of the mouse, Pages 260-295, Michael Steinmetz, Leroy Hood 12 - Monoclonal antibodies of murine and human origin: their generation, characterization and use, Pages 296-399, M.J. O'Hare Index, Pages 401-406 Edited By Gabriel S. Panayi And Chella S. David. Includes Bibliographies And Index.