Immunobiology of transfer factor : [proceedings of the fourth international workshop on transfer factor, held October 3-6, 1982 at the Given Institute of Pathobiology, Aspen, Colorado

Immunobiology of Transfer Factor compiles research papers presented at the Fourth International Transfer Factor Workshop, held at the Given Institute of Pathobiology in Aspen, Colorado, on October 3-6, 1982. This book focuses on the immunologic effects of transfer factor, which are supported by in vitro and in vivo experiments that indicate immunologically specific interactions between transfer factor and antigens. The topics include the selective removal of transfer factor activity with antigen, antigen-specific suppressor factor in human leukocyte dialysates, and specific suppressor dialysates from mice. The kinetics of immune response and production of transfer factor in bovine, dialyzable leukocyte extracts in pulmonary diseases, and mechanisms of action of human transfer factor are also elaborated. This compilation is suitable for microbiologists, immunologists, and specialists researching on transfer factor. Content: Inside Front Matter, Page ii Front Matter, Page iii Copyright, Page iv CONTRIBUTORS, Pages ix-xiii, K. Acott, Katsuhiko Akashi, Michel Allaray, Philippe Allard, Ralph G.I. Ashorn, Peter Baram, J. Berger, Jean Saint Blancard, J.F. Bonissent, William Borkowsky, Patrice Brunet-Lecomte, Denis Burger, Merrill W. Chase, Jean François Constant, Hervé de Muizon, Alain Blanchard de Vaucouleurs, J. Denis, K. Dogbe, Minter H. Dopson, Dominique Dormont, S. Doumerc, et al. PREFACE, Page xv ACKNOWLEDGMENTS, Page xvii Inside Front Cover, Pages xix-xxiii THE IMMUNOLOGICAL ENIGMA OF TRANSFER FACTOR, Pages 3-32, Merrill W. Chase HUMAN TRANSFER FACTOR: SPECIFICITY AND STRUCTURAL MODELS, Pages 33-49, Denis Burger, Arthur Vandenbark, R. Mark Vetto, Phillip Klesius HUMAN TRANSFER FACTOR: EXOGENOUS LABELLING, PURIFICATION, AND ROLE OF RIBONUCLEIC ACID SEGMENT, Pages 51-63, Gary V. Paddock, Gregory B. Wilson, Amanda M. Williams, H. Hugh Fudenberg SELECTIVE REMOVAL OF TRANSFER FACTOR ACTIVITY WITH ANTIGEN, Pages 65-74, Eskild A. Petersen, Lynn E. Greenberg, Thianda Manzara, Stephen J. Rozzo, Charles H. Kirkpatrick ANTIGEN-SPECIFIC INDUCER FACTOR IN HUMAN LEUKOCYTE DIALYSATES: A PRODUCT OF TH CELLS WHICH BINDS TO ANTI-V REGION AND ANTI-Ia REGION ANTIBODIES, Pages 75-90, William Borkowsky, H. Sherwood Lawrence ANTIGEN-SPECIFIC SUPPRESSOR FACTOR IN HUMAN LEUKOCYTE DIALYSATES: A PRODUCT OF TS CELLS WHICH BINDS TO ANTI-V REGION AND ANTI-Ia REGION ANTIBODIES, Pages 91-115, W. Borkowsky, J. Berger, R. Pilson, H.S. Lawrence ISOLATION AND PURIFICATION OF ANTIGEN-SPECIFIC INDUCER AND SUPPRESSOR FACTORS FROM POOLED LEUKOCYTE DIALYSATES OF UNSELECTED DONORS BY AFFINITY ADSORPTION, Pages 117-126, Robert S. Holzman, William Borkowsky, Robert Pilson, H. Sherwood Lawrence DIALYZABLE LEUKOCYTE EXTRACT CONTAINING TRANSFER FACTOR–ITS FUTURE IN VETERINARY MEDICINE, Pages 129-141, Phillip H. Klesius, Charles H. Kirkpatrick EFFECT OF DIALYZABLE LEUCOCYTE EXTRACT AND OTHER TISSUE DIALYSATES ON LISTERIA RESISTANCE, Pages 143-156, E. Karhumäki, K.J. E. Krohn OSTEOSARCOMA-SPECIFIC DIALYZABLE EXTRACTS: PROPHYLAXIS POST-SURGERY IN AN ANIMAL MODEL OF HUMAN OSTEOSARCOMA, Pages 157-174, Kwong Y. Tsang, H. Hugh Fudenberg, Gregory B. Wilson ANTIGEN-SPECIFIC TRANSFER FACTOR INDUCED IN MICE BY AN ATTENUATED VIRUS FROM THE TICK-BORNE ENCEPHALITIS COMPLEX BIOLOGICAL, HISTOLOGICAL AND CONCENTRATION STUDIES, Pages 175-187, Vlastimil Mayer, Eva Gajdošová, Eva Mitrová, Mária Valášková, Ctirad Oravec ANTIGEN-SPECIFIC SUPPRESSOR FACTOR IN HUMAN LEUKOCYTE DIALYSATES SUPPRESSES IN VIVO FOOTPAD REACTIVITY IN IMMUNIZED BALB/C MICE, Pages 189-196, W. Borkowsky, H.S. Lawrence SPECIFIC SUPPRESSOR DIALYSATES FROM MICE, Pages 197-202, J.M. Vich, D. Viza KINETICS OF IMMUNE RESPONSE AND PRODUCTION OF TRANSFER FACTOR IN BOVINE, Pages 203-212, B. Lesourd, M.R. Marescot, S. Doumerc, M. Thiollet, R. Moulias, J.F. Person, A. Ederlenis, Ch. Pilet TRANSFER OF CELL-MEDIATED IMMUNITY IN VITRO TO HUMAN LYMPHOCYTES USING DIALYZABLE LEUKOCYTE EXTRACTS FROM IMMUNE BURROS, Pages 213-230, Gregory B. Wilson, Martin L. Morin, Leonard D. Stuart, Amanda M. Williams, Eugenia Floyd, Gary V. Paddock, Louise Just, H. Hugh Fudenberg THE USE OF ANTIGEN SPECIFIC TRANSFER FACTOR IN THE MANAGEMENT OF INFECTIONS WITH HERPES VIRUSES, Pages 233-244, John M. Dwyer SPECIFIC BOVINE TRANSFER FACTOR FOR THE TREATMENT OF HERPES INFECTIONS, Pages 245-259, D. Viza, F. Rosenfeld, J. Phillips, J.M. Vich, J. Denis, J.F. Bonissent, K. Dogbe ORAL BOVINE TRANSFER FACTOR (OTF) USE IN THE HYPER-IgE SYNDROME, Pages 261-271, James F Jones, Michael J Schumacher, Wayburn S Jeter, Mary Jane Hicks DIALYZABLE LEUKOCYTE EXTRACTS IN PULMONARY DISEASES (LUNG CANCER AND RECURRENT BRONCHITIS), Pages 273-277, Jean Hainaut, Dominique Dormont, Gérald Haguenauer, Hervé de Muizon, Jean-Denis Heyraud, Philippe Allard, Xavier Foullon, Jean Pellegrin, Jean Kermarec CLINICAL USE OF LEUKOCYTE DIALYSATE (TRANSFER FACTOR) IN OSAKA AREA OF JAPAN, Pages 279-291, Katsuhiko Akashi, Shigenori Tanaka, Yasuto Okubo, Hideo Yamaguchi, Masayoshi Tanaka, Jiro Inui, Tomohiko Ohno, Tohru Nishihara, Koji Saito CLINICAL APPLICATIONS OF THE LEUKOCYTE MIGRATION INHIBITION ASSAY – NEW METHODS FOR DETERMINING TRANSFER FACTOR POTENCY AND FOR PREDICTING CLINICAL RESPONSE, Pages 293-310, H. Hugh Fudenberg, Gregory B. Wilson, Robert H. Keller, John F. Metcalf, Emily E. Paulling, E. Jane Stuart, Eugenia Floyd THE EFFECTS OF IMMUNE AND NONIMMUNE DIALYZABLE LEUCOCYTE EXTRACTS ON KLH AND HCH REACTIVITY IN UNPRIMED HUMAN RECIPIENTS: A DOUBLE BLIND STUDY., Pages 311-327, R.G.I. Ashorn, K.J. E. Krohn, A.A. Vandenbark, K. Acott MECHANISM(S) OF ACTION OF HUMAN TRANSFER FACTOR: INSIGHTS OBTAINED FROM STUDYING “ANTIGEN-LIBERATED TRANSFER FACTCR” SPECIFIC FOR TUBERCULIN, Pages 331-346, Gregory B. Wilson, H. Hugh Fudenberg, Gary V. Paddock, Kwong Y. Tsang, Amanda M. Williams, Eugenia Floyd DIALYZABLE LEUKOCYTES EXTRACTS (D.L.E.) AND THEOPHYLLINE TREATED LYMPHOCYTES, Pages 347-353, Jean Hainaut, Marc Thinot, Guy Rocquet, Patrice Brunet-Lecomte, Jean Saint Blancard, Michel Allaray, Alain Blanchard de Vaucouleurs, Jean Pierre Valleix, Jean Fraçois Constant DIALYZABLE LEUCOCYTE EXTRACT STIMULATES cAMP IN LYMPHOCYTES: LACK OF Fc-RECEPTOR INDUCTION OR NK-CELL ACTIVATION., Pages 355-364, Jorgen Jensen, Troels Herlin, Kristian Thestrup-Pedersen, Hugh Zachariae PORCINE SPLEEN CELL DIALYSATE INCREASES THE PHAGOCYTIC CAPACITY AND DECREASES PROSTAGLANDIN LEVELS OF PERITONEAL MACROPHAGES IN MOUSE, Pages 365-376, Ralph Ashorn, Erkki Seppälä, Eliisa Karhumäki, Heikki Vapaatalo, Kai Krohn INITIAL CHARACTERIZATION OF AN AMPLIATIVE NUCLEOSIDE ISOLATED FROM HUMAN DIALYZABLE LEUKOCYTE LYSATE, Pages 377-393, T.E. Schindler, D.L. Venton, P. Baram IMMUNOCHEMICAL AND PHYSICAL-CHEMICAL EVIDENCE FOR THE PRESENCE OF THYMOSIN ALPHA1-PEPTIDE IN DIALYZABLE LEUKOCYTE EXTRACTS, Pages 395-411, Gregory B. Wilson, Gary V. Paddock, Eugenia Floyd, Rebecca T. Newell, Minter H. Dopson THYMOSINα 1-LIKE MATERIAL IN DIALYSATES OF LEUKOCYTE EXTRACTS, Pages 413-421, Charles H. Kirkpatrick, Amanullah Khan, John E. McClure, Allan L. Goldstein TRANSFER FACTOR AND IMMUNE RNA, Pages 423-431, D. Viza, J. Phillips, F. Rosenfeld, J.M. Vich, C.R. Drogemuller, A. Faggioni, G. Pizza CLOSING COMMENTS, Page 433 Index, Pages 435-437