Immunobiology of Proteins and Peptides VII: Unwanted Immune Responses (Advances in Experimental Medicine and Biology, 347)

The articles in this volume represent papers delivered by invited speakers at the 7th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptide reagents which should have enormous potential in biological, therapeutic, and basic applications. This anticipated explosion has in fact since occurred and many applications of these peptides are now being realized. The seventh symposium focused on immune responses that have undesirable effects on the host, hence we named them unwanted immune responses. Two major aspects of unwanted immune responses were discussed at the symposium: Allergy and Autoimmunity. Front Matter....Pages i-xi Is there a Link Between the Nature of Agents that Trigger Mast Cells and the Induction of Immunoglobulin (IG)E Synthesis?....Pages 1-10 Immunogenetic Aspects of IgE-Mediated Responses....Pages 11-16 Structure and Function of the Low Affinity IgE Receptor....Pages 17-30 Characterization of the Human IgE Fc-Fc∈RIα Interaction....Pages 31-38 The Analysis of Mast Cell Function In Vivo Using Mast Cell-Deficient Mice....Pages 39-54 The Immunogenetic Basis of Collagen Induced Arthritis in Mice: An Experimental Model for the Rational Design of Immunomodulatory Treatments of Rheumatoid Arthritis....Pages 55-63 Suppression of Experimental Autoimmune Myasthenia Gravis by Epitope-Specific Neonatal Tolerance....Pages 65-75 T Cell Reactivity to Self and Allogeneic MHC-Peptides....Pages 77-79 Antiribosomal Antibodies in SLE, Infection, and Following Deliberate Immunization....Pages 81-92 Cross-Reactions of Anti-Immunoglobulin Sera with Synthetic T-Cell Receptor β Peptides: Mapping on a 3-Dimension Model....Pages 93-98 Stress Proteins in Autoimmunity....Pages 99-113 Polyclonal B Cell Activation and B Cell Cross-Reactivity During Autoantibody Production in Systemic Lupus Erythematosus....Pages 115-123 Autoantibody Activity and V Gene Usage by B-Cell Malignancies....Pages 125-133 Naturally Occurring Human Autoantibodies to Defined T-Cell Receptor and Light Chain Peptides....Pages 135-145 Natural Autoantibodies....Pages 147-159 Regulatory Autoantibody and Cellular Aging and Removal....Pages 161-192 B-Cell Origin of Cold Agglutinins....Pages 193-205 Initiation of Autoimmune Type 1 Diabetes and Molecular Cloning of a Gene Encoding for Islet Cell-Specific 37kd Autoantigen....Pages 207-220 Mapping of the Polypeptide Chain Organization of the Main Extracellular Domain of the α-Subunit in Membrane-Bound Acetylcholine Receptor by Anti-Peptide Antibodies Spanning the Entire Domain....Pages 221-228 Back Matter....Pages 229-231