Immunobiology of proteins and peptides V : vaccines : mechanisms, design, and applications

The following organizations also contributed to the Symposium Smith-Kline and French Laboratories Amgen v molecular genetic approach to the other subunit cistronic elements will enable a thorough investigation of primary features invo1ved in the tertiary and quaternary organization of this complex protein toxin.But of greater significance, an efficacious whooping cough vaccine component, free of the severe reactogenicity associated with prevailing pertussis vaccines, may be the most meaningful coro11ary of these investigations. REFERENCES Front Matter....Pages i-xi Developments toward a Recombinant Pertussis Vaccine....Pages 1-7 Prospects and Problems in Synthetic Vaccine Development: What did We Learn from the Cholera Toxin System?....Pages 9-16 New Concepts in Vaccines for Mucosal Non-Enteric Human Bacterial Pathogens....Pages 17-31 Stable Recombinant Avirulent Salmonella Vaccine Strains....Pages 33-47 Cytotoxic and Helper T-Lymphocyte Responses to Antibody Recognition Regions on Influenza Virus Hemagglutinin....Pages 49-63 Haemophilus b Oligosaccharide-CRM 197 and Other Haemophilus b Conjugate Vaccines: A Status Report....Pages 65-82 The Application of Molecular Biology to the Development of Novel Vaccines....Pages 83-98 Studies on the Clonality of the Antibody Response to a Protein Epitope....Pages 99-112 Anti-Idiotype Tumor Vaccines....Pages 113-127 A VH Region Synthetic Peptide Induces Antibodies Which Bind Native Immunoglobulins and Augment an Immune Response to Antigen....Pages 129-143 Enhancement of Primary and Secondary Immune Responses by Interferon-Gamma....Pages 145-152 Interleukin 1 and Its Synthetic Peptides as Adjuvants for Poorly Immunogenic Vaccines....Pages 153-160 Protection Induced by Synthetic Peptides Corresponding to Three Serotypes in Foot and Mouth Disease Virus....Pages 161-167 Characterization of a Synthetic Envelope Peptide of SRV-1 and SRV-2 Virus That Specifically Binds Rhesus Anti-SRV-1 and Anti-SRV-2 Neutralizing Antibodies....Pages 169-173 Synthetic Peptide Representing a T-Cell Epitope of CRM197 Substitutes as Carrier Molecule in a Haemophilus Influenzae Type B (HIB) Conjugate Vaccine....Pages 175-180 The Use of Mouse Class II MHC Peptides to Produce Site-Specific Monoclonal Antibodies....Pages 181-185 Epitope Mimicry by Anti-Idiotype Sequences in Reverse Orientation....Pages 187-190 Vaccine-Containing Biodegradable Microspheres Specifically Enter the Gut-Associated Lymphoid Tissue Following Oral Administration and Induce a Disseminated Mucosal Immune Response....Pages 191-202 Potentiation of Cell-Mediated Immune Responses Directed against P. Falciparum Sporozoite Peptide Vaccine by Immunomodulators....Pages 203-207 Detoxification of Pertussis Toxin by Site-Directed Mutagenesis....Pages 209-214 Filamentous Fusion Phage Cloning Vectors for the Study of Epitopes and Design of Vaccines....Pages 215-218 Recombinant-Derived Modified-Live Herpesvirus Vaccines....Pages 219-236 Advances in Understanding Structure-Function Relationships in Hepatitis B Virus (HBV) Envelope (ENV) Proteins....Pages 237-250 Antigenic Variation during Persistent Lentivirus Infections and Its Simplications for Vaccine Development....Pages 251-272 Antigenic Structure of the Fusion Glycoprotein of Respiratory Syncytial Virus....Pages 273-278 SIV Infected Rhesus Macaques: An AIDS Model for Immunoprevention and Immunotherapy....Pages 279-293 The Development of Molecular Vaccines against Malaria Sporozoites....Pages 295-313 Developing a Gonococcal Protein I Vaccine....Pages 315-327 The Genetics of the Immune Response to Trichinella spiralis Antigens in the Mouse....Pages 329-340 Modulation of Antibody Responses by Conjugates of Antigens with Monomethoxypolyethylene Glycol....Pages 341-351 Back Matter....Pages 353-356