Immunobiology and Prophylaxis of Human Herpesvirus Infections (Advances in Experimental Medicine and Biology, 278)

No one whose opinion deserves a moment's consideration can doubt that most of the great positive evils of the world are in themselves removable, and will, if human affairs continue to improve, be in the end reduced to narrow limits. J. S. Mill, Utilitarianism, II, 1863 Mill was not writing about herpesviruses, but had he known them as we do, he would have included them among the great positive evils of the world. They cause disease and premature death, and are very costly to our society. There is no loftier aim than to cure or prevent human infections with these viruses. The objective of much of the current research on herpesviruses is directed toward an understanding of the molecular mechanisms involved in initiation of infection, establish­ ment and termination of latent state, virus multiplication, and the destruction of cells which ultimately is the basis of the diseases caused by these viruses. At no time during the past 80 years, since members of the herpesvirus family were first discovered, has there been so much progress in our understanding of the biology of these viruses as in the past few years. Along with the development of a greater understanding of the molecular biol­ ogy of the well-known herpesviruses we have witnessed the isolation of new human herpes­ viruses. Front Matter....Pages i-ix Cellular and Growth-Factor Requirements for the Replication of Human Herpesvirus 6 in Primary Lymphocyte Cultures....Pages 1-8 Genomic Heterogeneity of Human Herpesvirus 6 Isolates....Pages 9-18 Replication of Human Herpesvirus 6 (HHV-6): Morphological Aspects....Pages 19-28 Exanthem Subitum and Human Herpesvirus 6 (HHV-6) Infection....Pages 29-37 Viral Pathology of Human Herpesvirus 6 Infection....Pages 39-47 A Live Varicella Vaccine....Pages 49-58 Differentiation between the Oka Varicella Vaccine Virus and American Wild-Type Varicella-Zoster Virus (VZV)....Pages 59-69 The T-Lymphocyte Response to Varicella-Zoster Viral Proteins....Pages 71-81 A Possible Role for Glycoprotein gpV in the Pathogenesis of Varicella-Zoster Virus....Pages 83-91 Changes in the Epidemiology of Cytomegalovirus....Pages 93-104 Antiviral Activities of a Human Monoclonal Antibody against Human Cytomegalovirus....Pages 105-113 Topological Effects of EBNA 1 on oriP ....Pages 115-124 Detection of 12- o -Tetradecanoylphorbol-13-Acetate-induced Cellular Proteins That Compete with the Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1) for Binding to a Site within the Epstein-Barr Virus oriP ....Pages 125-136 On the Biology of Epstein-Barr Virus Persistence: A Reappraisal....Pages 137-146 Epstein-Barr Virus, Burkitt’s Lymphoma, and an African Tumor Promoter....Pages 147-150 Regulation of Expression of the Glycoprotein Genes of Herpes Simplex Virus Type 1 (HSV-1)....Pages 151-164 Antigenic and Structural Properties of Mutants in Herpes Simplex Virus 1 Glycoprotein B....Pages 165-182 Yeast-derived Glycoprotein B-1 of Herpes Simplex Virus (HSV) as a Candidate for an HSV Vaccine....Pages 183-190 Herpes Simplex Virus Type 1 Infection in Mice with Severe Combined Immunodeficiency (SCID)....Pages 191-197 Transcripts Associated with Herpes Simplex Virus Latency....Pages 199-204 Pathogenesis and Latency of Herpes Simplex Virus Type 1 (HSV-1): An Ophthalmologist’s View of the Eye as a Model for the Study of the Virus-Host Relationship....Pages 205-209 Mechanisms of Restriction of Viral Gene Expression during Herpes Simplex Virus Latency....Pages 211-217 Detection of a Highly Conserved Region of Herpesviridae DNA by In Vitro Enzymatic Amplification: Application to the Detection of a New Human Herpesvirus....Pages 219-229 Prevalence of Specific Antibodies to Herpes Simplex Virus Type 2 as Revealed by an Enzyme-linked Immunoassay and Western Blot Analysis....Pages 231-242 Acyclovir: The Past Ten Years....Pages 243-253 Brovavir: Its Antiherpesviral Activity and Mode of Action....Pages 255-265 A Double-Blind Clinical Study in Patients with Herpes Zoster to Establish YN-72 (Brovavir) Dose....Pages 267-275 (S)-1-(3-Hydroxy-2-(phosphonylmethoxy)propyl)cytosine (HPMPC): A Potent Antiherpesvirus Agent....Pages 277-283 Whither Herpesviruses....Pages 285-291 Back Matter....Pages 293-296 No one whose opinion deserves a moment's consideration can doubt that most of the great positive evils of the world are in themselves removable, and will, if human affairs continue to improve, be in the end reduced to narrow limits. J.S. Mill, Utilitarianism, II, 1863 Mill was not writing about herpesviruses, but had he known them as we do, he would have included them among the great positive evils of the world. They cause disease and premature death, and are very costly to our society. There is no loftier aim than to cure or prevent human infections with these viruses. The objective of much of the current research on herpesviruses is directed toward an understanding of the molecular mechanisms involved in initiation of infection, establishƯ ment and termination of latent state, virus multiplication, and the destruction of cells which ultimately is the basis of the diseases caused by these viruses. At no time during the past 80 years, since members of the herpesvirus family were first discovered, has there been so much progress in our understanding of the biology of these viruses as in the past few years. Along with the development of a greater understanding of the molecular biolƯ ogy of the well-known herpesviruses we have witnessed the isolation of new human herpesƯ viruses Proceedings of the Fourth International Conference held in Fukuoka, Japan, October 4--6, 1989