Immune reactions and experimental models in rheumatic diseases : proceedings of the fourth Canadian Conference on Research in the Rheumatic Diseases, Toronto, October 15-17, 1970

The proceedings of the fourth Canadian conference on research in the rheumatic diseases held in Toronto in October 1970, this volume includes some 50 papers based on recent research carried out in Canada, the US, and abroad. The papers centre on two main themes: immunological aspects of the rheumatic diseases, and animal and experimental model diseases which have certain features in common with human rheumatic disorders. Preface 5 Contents 7 IMMUNE REACTIONS 11 Immune Reactions: Introduction and Summary Comments 11 The Release of Acid Hydrolases and Cationic Protein from Polymorphonuclear Leucocytes Exposed to Immune Complexes 20 Lysozyme (Muramidase) in Rheumatoid Arthritis 26 Proteolytic Mechanism of Allergic Inflammation with Reference to the Arthus Reaction 30 Immunoglobulin Complexes in Serum and Synovial Fluid of Persons with Rheumatoid Arthritis 42 The Complement System in Rheumatoid Synovitis: The Relationship of Synovial Fluid Complement Levels to the Clinical, Radiological, and Pathological Changes in Rheumatoid Arthritis 50 Complement Metabolism in Rheumatoid Arthritis 61 Serum and Synovial Fluid Proteins in Rheumatoid Arthritis 67 Serum and Synovial IgG, IgM, C3, and SMA-12 in Arthropathies 73 The Nature and Properties of Kinin-Forming Substances in Synovial Fluid in Rheumatoid Arthritis 78 Studies of the Induction of Lymphocyte Transformation by Synovial Fluid from Patients with Rheumatoid Arthritis 81 Clinical and Haematologic Criteria for the Diagnosis of Systemic Lupus Erythematosus 87 Immunoglobulins in the Normal Skin in Systemic Lupus Erythematosus 94 In Vitro Testing for Cellular Immunity to Denatured DNA in Systemic Lupus Erythematosus 100 Human Anti-endothelial Antibodies 107 Possible Immunological Mechanisms of Tissue Injury in Joint Diseases 112 A New Rheumatoid Factor Detectable with Sheep Erythrocytes Sensitized with Bovine Serum 116 Microbiological Antibody Studies in Séropositive and Séronégative Rheumatoid Arthritis 122 A Continuing Study of the Effect of Synovectomy on Living Articular Cartilage 130 The Effect of Synovectomy on Synovium and Cartilage in Rheumatoid Arthritis 135 EXPERIMENTAL MODELS 154 Experimental Models: Introduction and Summary Comments 154 Immune Complex Disease: Effect of Introduction of Immune Complexes into the Tracheobronchial Tree 155 The Effect of Iron-Dextran on Experimental Synovitis in Guinea-Pigs 164 Studies on the Pathogenesis of Experimental Arthritis in the Guinea-Pig 170 An Experimental Investigation of the Local Effects of Phenylbutazone, Gold Thiomalate, and Radioactive Colloidal Gold Administered Intra-articularly to Rabbits 175 Transplantation of Articular Cartilage in Domestic Fowls: A Model for the Study of the Immune Response to Allogeneic Cartilage 184 Fine-Structural Correlates of Endothelial Permeability in Vascular Fibrinoid Injury 189 A Murine Complement Defect as a Tool in the Analysis of Immunosuppression by Antilymphocyte Serum 199 The Possible Role of a Micro-organism in the Pathogenesis of Adjuvant-Induced Disease in Rats: The Effect of Total Body Radiation and Splenectomy 213 The Process of Ossification of Vertebral Ligaments in Experimental Adjuvant-Induced Arthritis 218 Aleutian Disease of Mink: A Virus-Induced Disease with Pathological Features Resembling Systemic Lupus Erythematosus 228 Experimental Models of Rubella Virus Infection 240 A Method of Organ Culture: Its Use as an Experimental Model 248 Tissue Culture Studies of Rheumatoid Synovial Cells 254 Microbiology of Synovial Membranes and Synovial Fluid in the Arthritides 257 Blocks in the Assembly of Immunoglobulin Polypeptide Chains in the Mouse Plasma Cell Tumours MOPC-173 and MPC-11 261 MISCELLANEOUS PAPER 269 The Role of Elastin in Health and Disease 269 The Role of Elastase in the Pathogenesis of the Connective Tissue Diseases 275 A Metabolic Site of Action of Cortisone of Hexosamine and Connective Tissue Metabolism 290 Collagen Synthesis in Normal and Injured Mature Rabbit Articular Cartilage 297 In Vivo Studies of Surfaces of Cartilage 300 Arthroscopy of the Knee 303 Tryptophan Metabolism in Rheumatoid Arthritis and Scleroderma 308 Gold 'Nephrosis' 314 Return to Work in Rheumatoid Arthritis 324 Total Hip Replacement 330 Ankylosing Spondylitis: A 20-Year Follow-up Review 335 Effects of Long-Term Treatment with Allopurinol on Iron Metabolism in Man 341 An Analysis of the Renal Response to Varying Plasma Urate Concentrations 346 The Influx of Uric Acid and Other Purines into Everted Jejunal Sacs of the Rat 352 Index of Authors 355