Immune Interferon: Properties and Clinical Applications (Pharmacology and Toxicology: Basic and Clinical Aspects Book 2)

Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons. Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma. They bring together the extensive findings from years of research since the discovery of the drug. Focusing on the drug itself and not particular brands, the book presents data on the properties of interferon-gamma, experimental data on its effects in cell cultures in vitro and on animals in vivo, the role that IFN-gamma plays in different diseases, and the results of its clinical applications. As interest in this versatile drug continues to grow, new avenues for its clinical use will continue to arise. Within a single source, Immune Interferon: Properties and Clinical Applications provides you with thorough information on all facets of interferon-gamma, from biological properties, to pharmaceutical processing, to clinical application. Immune Interferon: Properties and Clinical Applications......Page 4 Preface......Page 6 The Authors......Page 8 Abbreviations......Page 10 Contents......Page 12 2.2 INFgamma-producing cells. Inducers and inhibitors. Effect of aging......Page 19 2.3.1 The molecule of human IFNgamma......Page 22 2.3.2 The IFNgamma gene......Page 26 2.3.3 Molecular structure and biological activity of IFNgamma......Page 27 2.4 IFNgamma receptors......Page 30 3.1 Antiviral activity......Page 35 3.2 Antiproliferative activity......Page 38 3.3 Immunostimulatory activity......Page 42 3.4 Modulation of gene activity......Page 44 3.6 Antitumor activity......Page 45 chapter four: Molecular mechanisms of interferon gamma activities. Transmembrane signal transduction......Page 48 6.2 Gammaferon®......Page 53 6.3 Others......Page 55 Part two: Interferon gamma in pathological processes and its clinical application......Page 56 8.1 Parenteral......Page 58 8.3 Topical......Page 60 8.4 Inhalation......Page 61 8.5 Liposomes......Page 62 8.6 Other methods of delivery......Page 63 9.2 Rare and very rare side effects......Page 64 10.1.1 Herpes simplex virus type 1 and type 2 栀攀爀瀀攀猀 最攀渀椀琀愀氀椀猀......Page 66 10.1.2 Herpes zoster......Page 71 10.1.3 Herpetic and adenoviral eye infections......Page 72 10.1.4 Respiratory viral infections......Page 76 10.1.5.1 Condylomata acuminata......Page 77 10.1.5.3 Common warts......Page 79 10.1.6.1 Changes in cytokine profile......Page 80 10.1.6.2 Effect of different cytokines......Page 85 10.1.7 Hepatitis......Page 86 10.2.1.1.1 Tuberculosis......Page 88 10.2.1.2 Chlamydia......Page 92 10.2.2 Protozoa......Page 93 10.4 Nonviral extracellular pathogens......Page 94 11.1 Fibroproliferative diseases......Page 95 11.1.1.2 Fibrosis of the lung......Page 96 11.1.1.4 Systemic sclerosis and scleroderma......Page 98 11.2 Atherosclerosis......Page 99 11.4 Psoriasis......Page 102 11.5 Chronic granulomatous disease......Page 103 11.7 Rheumatoid arthritis......Page 105 11.8 Osteopetrosis......Page 110 11.9 Allergic disorders......Page 111 11.9.1 Atopic dermatitis......Page 112 11.9.2 Asthma......Page 113 11.9.3 Other allergic reactions......Page 114 11.10 Lupus erythematosus......Page 115 11.11 Severe traumas, burns, and surgical operations......Page 117 12.1 Background for using IFNgamma in malignancies......Page 119 12.2 Basocellular skin cancer 戀愀猀愀氀椀漀洀愀......Page 126 12.4 Lung cancer......Page 127 12.5 Colorectal cancer......Page 131 12.6 Malignant melanoma......Page 134 12.7 Renal cell carcinoma 刀䌀䌀......Page 140 12.8 Breast cancer......Page 145 12.9 Cervical cancer......Page 149 12.10 Gastric cancer......Page 152 12.11 Prostate cancer......Page 153 12.12 Ovarian cancer......Page 154 12.13 Cancer of the bladder......Page 156 12.14 Hepatocellular carcinoma......Page 157 12.15 Sarcomas......Page 160 12.15.1 Kaposi’s sarcoma......Page 161 12.16 Neuroblastoma......Page 162 12.17 Gliomas/glyoblastomas......Page 164 12.18.1 Chronic myelogenous leukemia......Page 165 12.18.3 Acute leukemias......Page 168 12.18.4 Lymphomas......Page 172 12.18.6 Multiple myeloma 䴀䴀......Page 173 12.19 Conclusions on the use of IFNgamma in malignant diseases......Page 175 chapter thirteen: General conclusions......Page 179 A......Page 181 B......Page 185 C......Page 194 D......Page 200 E......Page 204 F......Page 207 G......Page 211 H......Page 217 I......Page 225 J......Page 226 K......Page 228 L......Page 237 M......Page 243 N......Page 253 O......Page 257 P......Page 260 Q......Page 264 R......Page 265 S......Page 268 T......Page 281 U......Page 286 V......Page 287 W......Page 290 Y......Page 294 Z......Page 297 Interferon-gamma is a natural immune booster which has been synthesized and widely used in clinical cases ranging from infectious diseases to cancer. This title brings together the findings since the discovery of the drug. It presents data on the properties of interferon-gamma, experimental data on its effects, and its clinical applications. This volume summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities and clinical effects of immune interferon, also known as interferon-gamma (IFN-gamma) Cytokines are an important group of proteins realizing intercellular communications among cells of the same tissue (paracrine) or of different tissues (endocrine).