Immune Infertility : Impact of Immune Reactions on Human Fertility

This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology. Front Matter....Pages i-xi Front Matter....Pages 1-1 Proteomic Analysis of Human Spermatozoa....Pages 3-22 Methods of Analysis of Sperm Antigens Related to Fertility....Pages 23-47 Sperm Surface Proteomics....Pages 49-76 Sperm Functions Influenced by Immune Reactions....Pages 77-93 Front Matter....Pages 95-95 The Immune Privilege of the Testis....Pages 97-107 Immune Chemistry of ASA....Pages 109-123 Sperm-Specific T Lymphocytes....Pages 125-132 Site and Risk Factors of Antisperm Antibodies Production in the Male Population....Pages 133-147 Biologic Substrates Containing ASA....Pages 149-159 ASA in the Female....Pages 161-171 Sperm Immobilizing Antibody and Its Target Antigen....Pages 173-184 Front Matter....Pages 185-185 Male Autoimmune Infertility....Pages 187-196 Tests for Sperm Antibodies....Pages 197-207 Impact on Fertility Outcome....Pages 209-221 Sperm Antibodies and Assisted Reproduction....Pages 223-234 Treatment Modalities for Antisperm Antibodies-Mediated Immune Infertility....Pages 235-245 Front Matter....Pages 247-247 Antisperm Contraceptive Vaccine....Pages 249-261 Immune Contraception in Wildlife Animals....Pages 263-280 Immuno-interception of Fertility: Current Status of Vaccines Developed Against hCG and LHRH....Pages 281-293 Back Matter....Pages 295-302