Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation : Models in Discovery and Translation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog. These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios. Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenarios Categorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications Content: Front Matter , Page iii Copyright , Page iv Contributors , Pages xi-xiii , Gheath Alatrash, Maite Alvarez, Claudio Anasetti, Bruce R. Blazar, Craig A. Byersdorfer, Dominique Charron, Xiao Chen, James M. Coghill, Kenneth R. Cooke, William R. Drobyski, Jarrod A. Dudakov, Matthias Edinger, James L.M. Ferrara, Bree Foley, Daniel H. Fowler, Els Goulmy, Alan M. Hanash, Gerhard C. Hildebrandt, Geoffrey R. Hill, Petra Hoffmann, et al. Foreword , Pages xv-xvi , Jon J. van Rood Abbreviations , Pages xvii-xviii CH 1 - Overview of the immune biology of allogeneic hematopoietic stem cell transplantation , Pages 1-17 , Gérard Socié, Bruce R. Blazar CH 2 - The HLA system in hematopoietic stem cell transplantation , Pages 19-38 , Dominique Charron, Effie Petersdorf CH 3 - The impact of minor histocompatibility antigens in allogeneic stem cell transplantation , Pages 39-58 , Tuna Mutis, Els Goulmy CH 4 - In vivo imaging of graft-versus-host disease and graft-versus-leukemia , Pages 59-81 , Dennis B. Leveson-Gower, Robert S. Negrin CH 5 - Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans) , Pages 83-122 , Paul J. Martin, Robert B. Levy CH 6 - Strategies to improve post-transplant immunity , Pages 123-142 , Miguel-Angel Perales, Alan M. Hanash, Jarrod A. Dudakov, Marcel R.M. van den Brink CH 7 - Tumor-associated antigens , Pages 143-164 , Gheath Alatrash, Jeffrey J. Molldrem CH 8 - Impact of the conditioning regimen , Pages 165-171 , E. Holler, R. Storb CH 9 - Antigen presentation and antigen-presenting cells in graft-versus-host disease , Pages 173-194 , Christian A. Wysocki, Warren D. Shlomchik CH 10 - T-cell costimulation in graft-versus-host disease and graft-versus-leukemia effect , Pages 195-222 , Xue-Zhong Yu, Claudio Anasetti CH 11 - Th1/Th2 and Tc1/Tc2 cells: biology, experimental models and clinical translation , Pages 223-244 , Daniel H. Fowler CH 12 - Natural CD4 + CD25 + FOXP3 + regulatory T cells in graft-versus-host disease , Pages 245-270 , Matthias Edinger, Petra Hoffmann CH 13 - Role of Th17 cells and interleukin 17 in graft-versus-host disease and graft-versus-leukemia reactivity , Pages 271-297 , Xiao Chen, William R. Drobyski CH 14 - B and T cells in chronic graft-versus-host disease and graft-versus-leukemia , Pages 299-326 , Caron A. Jacobson, Jerome Ritz CH 15 - Natural killer cells in graft-versus-host disease and graft-versus-leukemia , Pages 327-356 , Bree Foley, Maite Alvarez, William Murphy, Jeffrey S. Miller CH 16 - Cytokines in graft-versus-host disease and graft-versus-leukemia , Pages 357-391 , Kate A. Markey, Kelli P.A. MacDonald, Geoffrey R. Hill CH 17 - Chemokines and graft-versus-host disease , Pages 393-424 , Kenneth R. Cooke, James M. Coghill, Gerhard C. Hildebrandt, Jonathan S. Serody CH 18 - Intracellular sensors of immunity and allogeneic hematopoietic stem cell transplantation , Pages 425-447 , Yaping Sun, Pavan Reddy CH 19 - Proteomics in graft-versus-host disease and graft-versus-leukemia , Pages 449-478 , Sophie Paczesny CH 20 - The endothelium in graft-versus-host disease and graft-versus-leukemia , Pages 479-492 , Olaf Penack CH 21 - Looking toward the future: an individualized approach to allogeneic transplantation , Pages 493-508 , Craig A. Byersdorfer, James L.M. Ferrara Index , Pages 509-518

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.

Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.

These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.

• Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedside
• Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenarios
• Categorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications

This book provides clinical and scientific researchers with a deep understanding of the current research and the implications for translational practice. By providing an overview of immune biology of HSCT, an explanation of immune rejection and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms which influence GVHD and GVL and transplantation success. With the use of illustrative figures, highlighted key issues, description of By providing an overview of the immune biology of hematopoietic stem cell transplantation(HSCT), an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a view of the complex processes involved.