Iminosugars as glycosidase inibitors [inhibitors] Nojirimycin and beyond

'Nowadays as a result of these manifold synthetic efforts a large number of inhibitors are available, that can be applied selectively for many different glycosidases. They are important aids to explain the construction and degradation particularly of complex carbohydrate side chains such as those found in glycoproteins and glycolipids. The amount of chemical and biochemical information has meanwhile grown to such an extent that it is almost impossible to keep track of the developments. Therefore it is particularly pleasing that contributions from experts for the individual fields are collected together in one work, thus providing a comprehensive overview. In this way this book gives a representative cross-section of the field. The book will be a generally interesting source of information for chemists and biochemists.' (from the foreword by H. Paulsen). A table which lists over 400 glycosidase inhibitors, more than 200 enzymes with 323 citations and over 1500 invaluable sets of data completes the book. Sec. 1. The Early Days Of Monosaccharides Containing Nitrogen In The Ring-- Sec. 2. Taxonomic Distribution Of Iminosugars In Plants And Their Biological Activities-- Sec. 3. Glycosidase Inhibition By Basic Sugar Analogs And The Transition State Of Enzymatic Glycoside Hydrolysis-- Sec. 4. Synthetic Methods For The Preparation Of Iminosugars-- Sec. 5. Iminosugars As Powerful Glycosidase Inhibitors- Synthetic Approaches From Aldonolactones-- Sec. 6. Isoiminosugars: Glycosidase Inhibitors With Nitrogen At The Anomeric Position-- Sec. 7. Synthesis And Biological Activity Of Castanospermine And Close Analogs. Sec. 8. Some Reflections On Structure-activity Relationships In Glycosidase-inhibiting Iminoalditols And Iminosugars-- Sec. 9. Potent Glycoside Inhibitors: Transition State Mimics Or Simply Fortuitous Binders?-- Sec. 10. Iminoalditols As Affinity Ligands For The Purification Of Glycosidases-- Sec. 11. Inhibitors Of Glycoprotein Processing. Arnold E. Stütz ; With A Foreword By H. Paulsen. Cover Title. Includes Bibliographical References And Index. Nowadays as a result of manifold synthetic efforts, a large number of inhibitors are available. They can be applied selectively for many different glycosidases. They are important aids to explain the construction and degradation, particularly of complex carbohydrate side chains such as those found in glycoproteins and glycolipids.