Imaging of the Human Brain in Health and Disease

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease Content: Front Matter , Page iii Copyright , Page iv List of ContributorS , Pages xi-xiv , Ruben Baler, James Robert Brašić, Guy Bormans, Cindy Casteels, Sofia N. Chatziioannou, Thilo Deckersbach, Lora Deuitch, Darin D. Dougherty, Andre C. Felicio, Joanna S. Fowler, Boris Frolov, Hironobu Fujiwara, Camille Garcia-Ramos, Emily Gean, Noble George, Sharmin Ghaznavi, Udi E. Ghitza, Roger N. Gunn, Christer Halldin, Jarmo Hietala, et al. Chapter One - Neuroimaging of Addiction , Pages 1-26 , Nora D. Volkow, Gene-Jack Wang, Joanna S. Fowler, Dardo Tomasi, Ruben Baler Chapter Two - Brain PET Imaging in the Cannabinoid System , Pages 27-36 , Dean F. Wong, Ayon Nandi, Eram Zaidi, Emily Gean, Andrew Horti, Boris Frolov, Noble George, James R. Brasic Chapter Three - Brain Imaging of Cannabinoid Receptors , Pages 37-79 , Cindy Casteels, Guy Bormans, Koen Van Laere Chapter Four - Human Brain Imaging of Opioid Receptors: Application to CNS Biomarker and Drug Development , Pages 81-98 , Udi E. Ghitza Chapter Five - Brain Imaging of Sigma Receptors , Pages 99-112 , Muneyuki Sakata, Jun Toyohara, Kiichi Ishiwata Chapter Six - Human Brain Imaging of Acetylcholine Receptors , Pages 113-160 , Jun Toyohara, Muneyuki Sakata, Kiichi Ishiwata Chapter Seven - Human Brain Imaging of Adenosine Receptors , Pages 161-186 , Masahiro Mishina, Yuichi Kimura, Kiich Ishiwata Chapter Eight - Human Brain Imaging of Dopamine D 1 Receptors , Pages 187-202 , Hironobu Fujiwara, Hidehiko Takahashi, Hitoshi Shimada, Yoshiro Okubo, Tetsuya Suhara Chapter Nine - Human Brain Imaging of Dopamine Transporters , Pages 203-240 , Andrea Varrone, Christer Halldin Chapter Ten - Imaging of Dopamine and Serotonin Receptors and Transporters , Pages 241-264 , Andre C. Felicio, A. Jon Stoessl Chapter Eleven - Imaging the Dopamine D 3 Receptor In Vivo , Pages 265-287 , Mark Slifstein, Eugenii A. Rabiner, Roger N. Gunn Chapter Twelve - Dopamine Receptors and Dopamine Release , Pages 289-339 , Robert M. Kessler Chapter Thirteen - Dopamine Receptor Imaging in Schizophrenia: Focus on Genetic Vulnerability , Pages 341-360 , Jussi Hirvonen, Jarmo Hietala Chapter Fourteen - Human Brain Imaging in Tardive Dyskinesia , Pages 361-371 , Sofia N. Chatziioannou, Emmanouil N. Rizos Chapter Fifteen - Human Brain Imaging of Autism Spectrum Disorders , Pages 373-406 , James Robert Brašić, Mona Mohamed Chapter Sixteen - Radiotracers Used to Image the Brains of Patients with Alzheimer’s Disease , Pages 407-416 , Noble George, Emily Gean, Ayon Nandi, James Robert Brašić, Dean F. Wong Chapter Seventeen - Human Brain Imaging of Anger , Pages 417-425 , Sharmin Ghaznavi, Thilo Deckersbach, Darin D. Dougherty Chapter Eighteen - Imaging Pain in the Human Brain , Pages 427-451 , Marco L. Loggia, Karin B. Jensen Chapter Nineteen - Imaging of Neurochemical Transmission in the Central Nervous System , Pages 453-484 , Lora Deuitch, Rajesh Narendran Chapter Twenty - Characterizing Recovery of the Human Brain following Stroke: Evidence from fMRI Studies , Pages 485-506 , Christian La, Brittany M. Young, Camille Garcia-Ramos, Veena A. Nair, Vivek Prabhakaran Index , Pages 507-517

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases.

Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease.

This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease.

• A focused introduction to imaging healthy and diseased brains
• Focuses on the primary neurotransmitter release
• Includes sigma, acetylcholine, opioid, and dopamine receptors
• Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

"Modern imaging techniques have allowed researchers to non-invasively peer into the human brain and investigate, among many other things, the acute effects and long-term consequences of drug abuse. Here, we review the most commonly used and some emerging imaging techniques in addiction research, explain how the various techniques generate their characteristic images and describe the rational that researchers use to interpret them. In addition, examples of seminal imaging findings are highlighted that illustrate the contribution of each imaging modality to the expansion in our understanding of the neurobiological bases of drug abuse and addiction, and how they can be parlayed in the future into clinical and therapeutic applications"-- Provided by publisher