Imaging, Cerebral Topography And Alzheimer's Disease (research And Perspectives In Alzheimer's Disease)

This volume contains the proceedings of the symposium organized by the Fondation IPSEN in Lille on October 16, 1989. It includes new data on imaging techniques (computed tomography, photon emission computed tomography, nuclear magnetic resonance), neuropathology, neurochemistry, and molecular biology. It provides a consistent interpretation of Alzheime&rgrave;s disease with respect to cerebral topography and its implications. Front Matter....Pages I-XIII Topography of Alzheimer’s Disease: Involvement of Association Neocortices and Connected Regions; Pathological, Metabolic and Cognitive Correlations; Relation to Evolution....Pages 1-17 Cellular Pathology in Alzheimer’s Disease: Implications for Corticocortical Disconnection and Differential Vulnerability....Pages 19-40 Distribution of Neurochemical Deficits in Alzheimer’s Disease....Pages 41-51 Topography of Lesions in Alzheimer’s Disease: A Challenge to Morphologists....Pages 53-67 Computer Tomography and Study of the Anatomical Changes in Alzheimer’s Disease....Pages 69-83 Could “Leuko-araïosis” Be Secondary to Wallerian Degeneration in Alzheimer’s Disease?....Pages 85-95 Topographical Comparison of Lesions in Trisomy 21 and Alzheimer’s Disease: A Study with PET, Anatomical and Neuropathological Investigations....Pages 97-107 Cognitive Deficits and Local Metabolic Changes in Dementia of the Alzheimer Type....Pages 109-119 Patterns of Cerebral Metabolism in Degenerative Dementia....Pages 121-128 Cortical Functional Impairment in Dementia of the Alzheimer Type: Studies with Positron Emission Tomography....Pages 129-137 Brain Imaging with SPECT in Alzheimer’s Disease....Pages 139-144 Hemodynamic Subtypes of Dementia of the Alzheimer Type: Clinical and Neuropsychological Characteristics....Pages 145-157 Nuclear Magnetic Resonance Study of Phospholipid Metabolites in Alzheimer’s Disease....Pages 159-165 Summary Comments on Presentations....Pages 167-171 Back Matter....Pages 173-176