Imaging and Focal Therapy of Early Prostate Cancer (Current Clinical Urology)

__Imaging and Focal Therapy of Early Prostate Cancer__ evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, __Imaging and Focal Therapy of Early Prostate Cancer__ is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer. Front Matter....Pages i-xiv Front Matter....Pages 1-1 Focal Therapy in Other Genitourinary Systems: Renal Cell Carcinoma....Pages 3-15 Changing Landscape of Prostate Cancer Favoring Low-Risk Prostate Cancer: Implications for Active Surveillance Versus Focal Therapy....Pages 17-36 Active Surveillance and Focal Therapy: A European Perspective....Pages 37-52 Pathologic Basis for Focal Therapy: Understanding Cancer Grade, Volume, and Spatial Location....Pages 53-71 Identifying the Index Lesion....Pages 73-80 Molecular Identification of the Indolent Versus Lethal Tumor....Pages 81-94 Front Matter....Pages 95-95 Biopsy Strategies to Detect Small Prostate Cancers....Pages 97-101 3D Image-Guided Mapping Biopsy for Defining Spatial Distribution of Prostate Cancer....Pages 103-117 Stereotactic, Image-Guided Robotic Biopsy....Pages 119-132 Multimodality MRI-Guided Targeting....Pages 133-140 Quality Assurance in Prostate Biopsy Sampling, Processing, and Reporting: A New Pathologic Paradigm for Prostate Cancer Diagnosis....Pages 141-151 Front Matter....Pages 153-153 Contrast-Enhanced Ultrasonography....Pages 155-164 Prostate Elastrography....Pages 165-172 Multiparametric Magnetic Resonance Imaging Approaches in Focal Prostate Cancer Therapy....Pages 173-202 Nanomedicines for Diagnosis and Treatment of Prostate Cancer....Pages 203-217 New Horizons in Molecular Imaging of Prostate Cancer....Pages 219-234 Front Matter....Pages 235-235 Prostate Focal Therapy: Definitions and Common Terminology....Pages 237-244 Selection Criteria for Focal Therapy of Prostate Cancer....Pages 245-253 Standardisation of Focal Therapy Protocols....Pages 255-269 Front Matter....Pages 271-271 High Intensity Focused Ultrasound....Pages 273-282 Front Matter....Pages 271-271 Photodynamic Therapy for Early Prostate Cancer....Pages 283-295 MRI-Guided Laser Ablation for Localized Prostate Cancer....Pages 297-307 Cell Electroporation Mechanisms and Preclinical Foundation for Focal Therapy....Pages 309-329 Histotripsy....Pages 331-343 Cryoablation....Pages 345-353 Optimizing Ablative Therapy: Manipulating the Microenvironment....Pages 355-366 Front Matter....Pages 367-367 Setting Rules for Post-ablation and Follow-Up....Pages 369-382 Roadmap for Focal Therapy....Pages 383-388 Optimizing Ablative Therapy Manipulating the Microenvironment....Pages E1-E1 Back Matter....Pages 389-396 This book evaluates the trend to treat low risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. It examines the latest clinical applications of image-guided diagnosis and treatment.