IGFs in the nervous system (insulin-like growth factors in the nervous system) : Proceedings

In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated. The book contains black-and-white illustrations. Front Matter....Pages I-XI New Experimental Models for the Study of IGF and IGF-Binding Protein Action in the Brain....Pages 1-16 The Insulin-like Growth Factor-I Receptor and the Central Nervous System: Mechanisms Involved in the Prevention of Apoptosis....Pages 17-27 IGF-I in Neuronal Differentiation and Neuroprotection....Pages 28-46 Insulin-like Growth Factor I: Regulation and Interactions During Aging-Induced Cognitive Decline and Impairment Within the Hippocampus....Pages 47-59 The Role of IGF-I in Cerebellar Granule Cell Survival and Terminal Differentiation....Pages 60-71 Regulation of Oligodendrocyte Development and CNS Myelination by IGF-I: Prospects for Disease Therapy....Pages 72-83 IGF-I and Glycosaminoglycans Improve Peripheral Nerve Regeneration and Motor Neuron Survival in Models of Motor Neuron Disease....Pages 84-95 The Potential of IGF-I as a Neuronal Rescue Agent....Pages 96-104 Neurobiology of rhIGF-I: Rationale for Use in Motor Neuron Disease....Pages 105-114 rhIGF-I for the Treatment of Neuromuscular Disorders....Pages 115-126 Insulin-like Growth Factor-I Effects on ADP-Ribosylation Processes and Interactions with Glucocorticoids During Maturation and Differentiation of Astroglial Cells in Primary Culture....Pages 127-134 Anti-Insulin-like Growth Factor I Antibodies Affect Locomotion and Passive Avoidance Performances in Sprague-Dawley Rats....Pages 135-144 Neuroprotective Effect of GPE Pretreatment on Rat Hippocampal Organotypic Cultures Exposed to NMDA....Pages 145-150 Expression of IGF-I and IGF-I Receptor mRNA in Sural Nerves of Diabetic Patients....Pages 151-156 Back Matter....Pages 157-159