Idiotypes in Medicine: Autoimmunity, Infection and Cancer. Autoimmunity, Infection and Cancer

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines. Content: List of Contributors , Pages vii-xii Anti-Idiotypes as vaccines: Theoretical considerations , Pages 3-10 , Alfred Nisonoff Anti-idiotypes , Pages 11-18 , Constantin A. Bona X-ray crystallographic studies of the idiotypic cascade , Pages 19-36 , Nenad Ban, Alexander McPherson The structure and thermodynamics of antibody-protein antigen interactions , Pages 37-50 , Bradford C. Braden, Roberto J. Poljak Introduction—Idiotypes and anti-idiotypes , Pages 53-63 , Mahmoud Abu-Shakra, Dan Buskila, Yehuda Shoenfeld Cross-reactive idiotypes in human lupus families , Pages 65-74 , Pierre Youinou Idiotypes of anti-DNA antibodies , Pages 75-88 , Dan Buskila, Mahmoud Abu-Shakra, Yehuda Shoenfeld Idiotypes of anti-Sm antibodies , Pages 89-93 , Howard Dang, Norman Talal Idiotypes of anti-Ro and anti-La , Pages 95-97 , Yaron Bar Dayan, Howard Amital, Yehuda Shoenfeld Idiotypes on autoantibodies in myasthenia gravis , Pages 99-106 , Ann Kari Lefvert Idiotypes of ANCA , Pages 107-112 , Elena Csernok, Wolfgang L. Gross Ig genes and idiotype of anti-mitochondrial antibodies in primary biliary cirrhosis , Pages 113-118 , Patrick S.C. Leung, M. Eric Gershwin Idiotypes of anti-phospholipid antibodies , Pages 119-128 , Ronit Bakimer, Yehuda Shoenfeld Anti-idiotypic antibodies against human insulin autoantibodies (IAA) , Pages 129-134 , S. Kyurkchiev, M. Stamenova, V. Manolova, V. Tsvetkova, L. Dakovska, I. Kehayov Molecular and cellular aspects of human rheumatoid factor production and idiotypes , Pages 135-155 , Rizgar A. Mageed, Sasha P. Moyes, Keith M. Thompson, Jacob B. Natvig Idiotypes of anti-thyroglobulin antibodies , Pages 157-163 , Yaron Tomer Idiotypes of human platelet-specific antibodies , Pages 165-187 , Thomas J. Kunicki, Diane J. Nugent Idiotypes of platelet associated antibodies (autoimmune thrombocytopenia) , Pages 189-192 , Mahmoud Abu-Shakra, Dan Buskila, Yehuda Shoenfeld Idiotypes of natural autoantibodies and monoclonal gammopathies , Pages 193-203 , Mahmoud Abu-Shakra, Dan Buskila, Yehuda Shoenfeld Idiotypes and anti-idiotypes in allergy , Pages 205-215 , Marc G. Jacquemin, Jean-Marie R. Saint-Remy Anti-idiotypes to autoantibodies in therapeutic preparations of normal polyspecific human IgG (intravenous immunoglobulin, IVIg) , Pages 217-225 , Sergio H Spalter, Srini Kaveri, Michel D Kazatchkine Manipulation of autoantibody idiotypes in autoimmune diseases , Pages 227-238 , Dan Buskila, Mahmoud Abu-Shakra, Yehuda Shoenfeld Anti-idiotypic monoclonal antibody (mAb) to anti-CD4 mAb as surrogate of human CD4 antigen (Ag) for active immunotherapy of autoimmune diseases , Pages 239-254 , Federico Perosa, Marco Scudeletti, Franco Indiveri, Franco Dammacco Introduction , Page 257 , Ronald C. Kennedy Anti-idiotypic studies of the glycoprotein B (gB, UL55) complex of human cytomegalovirus:: Mimicry of a neutralizing epitope and development of diagnostics , Pages 259-268 , Eilleen S. Tackaberry, Josée Hamel, Bernard R. Brodeur Anti-idiotype antibody in HIV-1-infected thrombocytopenic patients , Pages 269-279 , S. Karpatkin, M.A. Nardi An electron microscopic view of the geometry and dynamics of idiotype—anti-idiotype interactions , Pages 281-291 , Kenneth H. Roux, Neil S. Greenspan Probing human antibody diversity in HIV infection , Pages 293-301 , Saoussen Karray, Moncef Zouali Anti-Idiotype Mimics of Pseudomonas Aeruginosa Surface Polysaccharides , Pages 303-315 , John R. Schreiber Modulation of the immune response to simian virus 40 large tumor antigen via idiotype—anti-idiotype interactions , Pages 317-329 , Michael H. Shearer, Harvey I. Pass, Michele Carbone, Ronald C. Kennedy The perpetual network theory and its putative applications: 21 Years later , Pages 331-340 , Hildegund C.J. Ertl An anti-idiotypic antibody as a functional mirror image of a viral antigen , Pages 341-345 , Yasmin Thanavala Anti-idiotype to bluetongue virus VP7 antigen: Potential diagnostic reagent and vaccine , Pages 347-355 , En-Min Zhou, Min Lin An idiotype vaccine against gram-negative bacterial sepsis , Pages 357-368 , Ronald E. Ward Yeast killer toxin-like antibodies in experimental and clinical candidasis , Pages 369-380 , L. Polonelli, F. De Bernardis, S. Conti, M. Gerloni, A. Cassone Anti-idiotypic antibodies and idiotypic T cell selection in HIV infection , Pages 381-394 , Sybille Müller, Michael Grant Probing human polysaccharide-specific antibody repertoires using anti-idiotypes , Pages 395-405 , Alexander H. Lucas Anti-idiotypic antibodies in HIV-infected patients to a neutralizing mab and its complementarity determining regions , Pages 407-414 , Michael Levi, Jorma Hinkula, Britta Wahren Esptein-barr virus-induced autoimmunity through anti-idiotype studies , Pages 415-426 , Carlo Garzelli, Marina Incaprera, Agostino Bazzichi, Giuseppe Falcone Introduction , Pages 429-430 , Soldano Ferrone Cancer therapy with anti-idiotypic antibodies , Pages 431-439 , Ofer Merimsky, Pnina Fishman, Yehuda Shoenfeld Immunotherapy of cancer patients with anti-idiotype vaccines , Pages 441-453 , Malaya Bhattacharya-Chatterjee, Heinz Köhler, Kenneth A. Foon Anti-idiotype antibodies mimicking carcinoembryonic antigen , Pages 455-459 , Marc Monestier Immunological and molecular characterization of an idiotypic cascade specific for the human carcinoembryonic antigen , Pages 461-475 , Michael Neumaier, Franz-Josef Gaida, Dagmar Pieper, Mark A. Sherman, John E. Shively Anti-idiotypic antibodies that mimic the colorectal cancer antigen CO17-1A/GA733: Twelve years of pre-clinical and clinical studies , Pages 477-489 , Dorothee Herlyn, Rajasekharan Somasundaram, Lutz Jacob, Weiping Li, Jan Zaloudik, Haruhiko Maruyama, Andrea Benden, David Harris, Michael Mastrangelo Idiotypic network responses and anti-idiotypes in cancer therapy , Pages 491-498 , Jan Fagerberg, Peter Ragnhammar, Hkan Mellstedt Anti-idiotypes in ovarian cancer , Pages 499-509 , U. Wagner, H. Schlebusch, J. Schmolling, J. Reinsberg, D. Krebs Anti-idiotype antibodies in renal cell carcinoma , Pages 511-516 , H. Uemura, E. Oosterwijk Clinical studies with anti-idiotypic monoclonal antibody BEC2 that mimics GD3 ganglioside , Pages 517-521 , Paul B. Chapman The anti-idiotypic approach to active specific immunotherapy of malignant melanoma , Pages 523-536 , Xinhui Wang, Smruti Desai, Elvyra J. Noronha, Abraham Mittelman, Soldano Ferrone Subject index , Pages 537-540