Ibuprofen: A Critical Bibliographic Review (Taylor & Francis Series in Pharmaceutical Sciences)

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data. Book Cover......Page 1 Half-Title......Page 2 Title......Page 4 Copyright......Page 5 Contents......Page 6 Preface......Page 8 1 History and Development of Ibuprofen......Page 10 2 The Medicinal Chemistry of Ibuprofen......Page 32 3 The Pharmaceutics of Ibuprofen......Page 57 4 The Pharmacokinetics of Ibuprofen in Humans and Animals......Page 88 5 Pharmacology and Toxicology of Ibuprofen......Page 141 6 Therapeutics of Ibuprofen in Rheumatic and Other Chronic and Painful Diseases......Page 263 7 Safety and Efficacy of Non-Prescription (OTC) Ibuprofen......Page 333 8 Use of Ibuprofen in Dentistry......Page 386 9 Gastrointestinal Adverse Drug Reactions Attribute to Ibuprofen......Page 407 10 Renal Effects of Ibuprofen......Page 433 11 Adverse Drug Reactions Attributed to Ibuprofen: Effects Other Than Gastrointestinal......Page 467 12 Human Toxicity of Ibuprofen......Page 506 Appedix I Some Brands of Ibuprofen in Various Countries......Page 525 Appendix II Methods for Analysis of Ibuprofen in Biological Systems......Page 532 Index......Page 537 "Ibuprofen is used throughout the world for the treatment of pain, inflammation and fever in a variety of conditions and has an excellent safety record. This definitive reference is the first on ibuprofen in thirty years of its use. It provides a comprehensive and critical review of the basic scientific and clinical data relating to both efficacy and safety."--BOOK JACKET Provides a review of the basic science and clinical aspects of ibuprofen. Nowhere else is this breadth and depth of scientific and clinical data available in one source. Invaluable to academia, industry and clinicians in this field. The history of ibuprofen began over 40 years ago and is inextricably linked to understanding of the concepts of the pathogenesis of inflammatory diseases and the actions of therapeutic agents used at that time.