IARC monographs on the evaluation of carcinogenic risks to humans, volume 89, Smokeless Tobacco and Some Tobacco-specific N-Nitrosamines : this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic

This eighty-ninth volume of the IARC Monographs is the third and last of a series on tobacco-related agents. Volume 83 reported on the carcinogenicity of tobacco smoke and involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC, 2004a). Volume 85 summarized the evidence on the carcinogenic risk of chewing betel quid with and without tobacco (IARC, 2004b). That volume explored the variety of products chewed in South Asia and other parts of the word that contain areca nut in combination with other ingredients, often including tobacco. In this eighty-ninth volume, the carcinogenic risks associated with the use of smokeless tobacco, including chewing tobacco and snuff, are considered in a first monograph. The second monograph reviews some tobacco-specific nitrosamines. These agents were evaluated earlier in Volume 37 of the Monographs (IARC, 1985), and information gathered since that time has been summarized and evaluated. Smokeless Tobacco -- 1. Description Of Smokeless Tobacco Practices -- 2. Studies Of Cancer In Humans -- 3. Studies Of Cancer In Experimental Animals -- 4. Other Data Relevant To An Evaluation Of Carcinogenicity And Ts Mechanisms -- 5. Summary Of Data Reported And Evaluation -- 6. References -- -- Some Tobacco-specific N-nitrosamines -- 1. Exposure Data -- 2. Studies Of Cancer In Humans -- 3. Studies Of Cancer In Experimental Animals -- 4. Other Data Relevant To An Evaluation Of Carcinogenicity And Ts Mechanism -- 5. Summary Of Data Reported And Evaluation -- 6. References -- Glossary -- List Of Abbreviations. This Publication Represents The Views And Expert Opinions Of An Iarc Working Group On The Evaluation Of Carcinogenic Risks To Humans, Which Met In Lyon, 5-12 October 2004. Cumulative Cross Index To Iarc Monographs (p. 593-626). Includes Bibliographical References.