Hypoxia: From Genes to the Bedside (Advances in Experimental Medicine and Biology, 502)

Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others. Front Matter....Pages i-xv John T. Reeves, MD....Pages 1-5 Genetic lessons from high altitude....Pages 7-11 Genes, environment, and exercise....Pages 13-20 Skeletal muscle angiogenesis....Pages 21-38 Leukocyte-endothelial interactions in environmental hypoxia....Pages 39-60 Hypoxia training for sea-level performance....Pages 61-73 The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise....Pages 75-88 Update: High altitude pulmonary edema....Pages 89-106 Phylogenetic comparison and artificial selection....Pages 107-132 Genetic and environmental adaptation in high altitude natives....Pages 133-151 Common themes of adaptation to hypoxia....Pages 153-167 Biology of erythropoietin....Pages 169-187 Lessons to better understanding of hypoxia sensing....Pages 189-205 Erythropoietin use and abuse....Pages 207-224 Mountaineering in thin air....Pages 225-236 Weight loss at high altitude....Pages 237-247 The heme oxygenase system and cellular defense mechanisms....Pages 249-272 Hypoxia-inducible factor in brain....Pages 273-291 Proton-gated cation channels — neuronal acid sensors in the central and peripheral nervous system....Pages 293-304 Structure function relationships of ENaC and its role in sodium handling....Pages 305-314 Transepithelial sodium and water transport in the lung....Pages 315-338 Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?....Pages 339-348 Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia....Pages 349-363 The pVHL-HIF-1 system....Pages 365-376 Interval hypoxic training....Pages 377-399 Gene transfer and metabolic modulators as new therapies for pulmonary hypertension....Pages 401-418 Chronic mountain sickness....Pages 419-437 International Working Group For Chronic Mountain Sickness....Pages 439-440 Late and Amended Abstracts....Pages 441-442 Back Matter....Pages 443-445