Hypotensive Peptides : Proceedings of the International Symposium October 25–29, 1965, Florence, Italy

The papers collected in this volume were presented at the International Symposium on Hypotensive Peptides held in Flor­ ence, Italy, on October 25-29, 1965. The purpose of the meeting was to bring together scientists of fourteen countries ranging from the chemist to the surgeon, who usually do not speak a common language and for whom it would be quite difficult to follow the latest developments in fields allied to, but still some­ what removed from their basic interest. Their reports sum­ marized their recent progress and current achievements, and gave indication of the trend that future research on hypotensive peptides may take. Various aspects of the structure and function of brady­ kinin, kallidin, kallikrein, gastrin, eledoiSin, physalaemin, sub­ stance P, and related substances were discussed during the nine sessions. The first session was devoted to the chemistry of peptides. This was followed in loose order by reports dealing with the structure of some newer peptides, with kininogen, and with enzymes that release or inactivate peptides. Subsequently, reports on the physiological, pharmacological, pathological, and clinical importance of kinins, kallikrein, and eledoisin were presented. One entire session was devoted to substance P. At the closing session two motion pictures demonstrated the effect of the peptides on the circulation. The appendix of this volume contains the report of the international Committee on Nomenclature. Front Matter....Pages i-xxvi Automated Peptide Synthesis....Pages 1-13 Synthesis of All-D-Isomers in the Bradykinin Series....Pages 14-22 The Search for Peptides with Specific Antibradykinin Activity....Pages 23-31 Discussion....Pages 31-33 Recent Developments in the Chemistry of Gastrin....Pages 34-44 The Influence of Substitution or Omission of an Amino Group on the Hypotensive Activity of the C-Terminal Sequences of Eledoisin....Pages 45-54 Novel Techniques for the Synthesis of Linear and Cyclic Peptides....Pages 55-62 Polypeptides Active on Plain Muscle in the Amphibian Skin....Pages 63-75 A Bradykinin-Like Endecapeptide of the Skin of Phyllomedusa Rohdei....Pages 76-85 Synthetic Peptides Related to Physalaemin and Eleodoisin....Pages 86-92 Characterization of Kinins in Wasp Venom....Pages 93-104 Studies of Bovine Plasma Kininogen, Ornitho-Kallikrein, and Ornitho-Kinin....Pages 105-115 Enzymatic Kinin Release from Kininogen and from Low-Molecular Compounds....Pages 116-129 The Purification and Some Properties of Two Different Kallidinogens from Human Plasma....Pages 130-138 Physiological Influence on the Liberation of Human Plasma Kinin at Low Temperatures....Pages 139-148 Purification and Properties of Bradykininogen and of the Bradykinin-Releasing and -Destroying Enzymes in Snake Venom....Pages 149-160 Human Salivary Kallikrein and Liberation of Colostrokinin....Pages 161-174 Studies of the Specificity of Kinin-Forming Enzymes....Pages 175-184 Demonstration of the Presence of Two Separate Kinin-Forming Systems in Human and Other Plasma....Pages 185-197 Quantitative Studies of Kinin-Releasing Enzymes in Plasma....Pages 198-210 Immunologic Studies of Components of the Kallikrein-Kinin System....Pages 211-220 Kininogenases, Kininases, and Their Inhibitors....Pages 221-234 Inactivation and Potentiation of the Effects of Bradykinin....Pages 235-251 The Role of Cathepsins in the Inactivation of Plasma Kinins....Pages 252-262 The Physiological and Pathological Role of the Kallikrein-Kallidin System....Pages 263-274 Kallikrein and Vasodilatation in the Salivary Gland....Pages 275-280 Further Experiments on the Role of Plasma Kinins as Mediators of Functional Vasodilatation in Glandular Tissues....Pages 281-288 Effect of Bradykinin on Submandibular Salivary Gland Permeability....Pages 289-297 A Radio-Immunoassay for Bradykinin....Pages 298-304 Self-Antagonism of Bronchoconstriction Induced by Bradykinin and Angiotensin....Pages 305-313 The Effect of Bradykinin and Angiotensin on Ganglionic Transmission....Pages 314-328 Polypeptide Receptor Mechanisms: Influence of pH....Pages 329-340 Sensitization of Smooth Muscle to the Action of Plasma Kinins by Chymotrypsin....Pages 341-343 Potentiation of the Effect of Bradykinin....Pages 344-355 Bradykinin-Potentiating Factor....Pages 356-367 The Influence of Intra-Arterial Infusions of Synthetic Bradykinin on Flow and Composition of Lymph in Dogs....Pages 368-374 The Action of Hypotensive Polypeptides on the Pulmonary Arterial Pressure....Pages 375-384 Bradykinin and Pulmonary Vascular Permeability in Isolated Blood-Perfused Rabbit Lungs....Pages 385-395 Venoconstriction Induced by Bradykinin in the Rabbit Ear....Pages 396-406 Cardiovascular Actions of Physalaemin....Pages 407-413 Hemodynamic Effects of Physalaemin and of Some Synthetic Eledoisin and Physalaemin-like Polypeptides....Pages 414-429 The Effects of Eledoisin and Bradykinin on the General and Visceral Circulation....Pages 430-440 The Effects of Bradykinin and Substance P on the Specialized Ventricular Conducting System of Dog Heart....Pages 441-450 Microcirculatory Effects of Polypeptides....Pages 451-462 The Proteolytic Process in Pancreatic Disease....Pages 463-473 Kinin Formation and Destruction in Fluid Produced by a Strangulated Segment of Ileum in the Rat....Pages 474-484 Fibrinolysis and Vasoactive Peptides in Anaphylaxis....Pages 485-505 Treatment of Experimental and Human Atherosclerosis with Bradykinin-Antagonist, Pyridinolcarbamate: A Preliminary Report....Pages 506-521 Some Physiological and Pathological Roles of Kininogen and Kinins....Pages 522-535 Bradykininogen in the Blood of Women during Pregnancy, Labor, and Puerperium....Pages 536-544 Pharmacologically Active Peptides in Trypanosome Infections....Pages 545-550 Possible Modes of Kinin Formation in Some Pathological States in Man....Pages 551-564 Biochemical and Physiologic Studies of the Kinins in Carcinoid Syndrome....Pages 565-578 Occurrence of a Polypeptide Biologically not Distinguishable from Bradykinin in Human Pulmonary Carcinoma....Pages 579-582 In Memory of Sir John Gaddum, F.R.S.....Pages 583-583 Purification of Substance P....Pages 584-593 Studies of Substance P....Pages 594-607 Substance P in Lipid Extracts of Brain Tissue....Pages 608-620 The Role of Release of Acetylcholine in the Gut-Contracting Action of a Brain Polypeptide....Pages 621-632 Contribution to the Sedative Action of Substance P....Pages 633-640 The Hypotensive Action of Eledoisin in Subjects with Arterial Hypertension ....Pages 641-642 Remarks....Pages 643-643 Trasylol....Pages 644-645 Concluding Remarks....Pages 646-647 Back Matter....Pages 648-660